Lecture_5_protein_structure_2011

Lecture_5_protein_structure_2011 - Introduction to...

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Introduction to Biophysics Lecture 5 Proteins Structure
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DNA structure : James Watson, Francis Crick, Rosalind Franking X-rays: Wilhelm Röntgen Information theory: Claudy E. Shannon 1895 On 8 Nov, 1895, Wilhelm Conrad Röntgen (accidentally) discovered an image cast from his cathode ray generator, projected far beyond the possible range of the cathode rays (now known as an electron beam). Further investigation showed that the rays were generated at the point of contact of the cathode ray beam on the interior of the vacuum tube, that they were not deflected by magnetic fields, and they penetrated many kinds of matter. A week after his discovery, Rontgen took an X-ray photograph of his wife's hand which clearly revealed her wedding ring and her bones. The photograph electrified the general public and aroused great scientific interest in the new form of radiation. Röntgen named the new form of radiation X- radiation (X standing for "Unknown"). Hence the term X- rays (also referred as Röntgen rays, though this term is unusual outside of Germany).
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Proteins hemoglobin
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Ribosome – molecular machine that synthetizes proteins
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Biological molecules consist of: C, H, O, N, P isomers are compounds with the same molecular formula but different structures A simple example of isomerism is given by propanol: C 3H8O (or C3H7OH) propan-1-ol (n-propyl alcohol; I), propan-2-ol (isopropyl alcohol; II) and methoxyethane III Isomers:
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Chain isomerism Position isomerism Functional group isomerism Chiral Isomers:
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Rotamers: The conformational state shows how the atoms are arranged in space. The conformational state of a molecule has a profound impact on what it does, and much
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This note was uploaded on 12/09/2011 for the course PHYS 570 taught by Professor Staff during the Fall '08 term at Purdue.

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Lecture_5_protein_structure_2011 - Introduction to...

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