From%20Genomics%20to%20Proteomics-%20Bio%20230-%2011-07-2011

From%20Genomics%20to%20Proteomics-%20Bio%20230-%2011-07-2011...

Info iconThis preview shows pages 1–10. Sign up to view the full content.

View Full Document Right Arrow Icon
From Genes to Proteins the world of ‘omics’ Devika Sirohi Monday- November 7th, 2011
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
CELLLS (Part 1) is due today by 5 PM. You may submit the assignment through Blackboard- Assignments. Exam 4 is next Monday (November 14) at 8 PM (PHYS -112 & 114) Please collect Exam 3 after class today Announcements Last Name TA A - E Basudev BACK F - J Park K - M Cal N - S Yamini FRONT T - Z Devika
Background image of page 2
Recap Where? When? How much? Control of gene expression Transcriptional-level control: whether and how often a gene can be transcribed Processing-level control: how a pre-mRNA is processed into a mature mRNA (e.g. alternative splicing) Translational-level control: whether and how often mRNA can be translated, also mRNA stability
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Recap Control of transcription and promoter region by epigenetics, including DNA methylation and histone modifications Control of transcription and promoter region by transcription factors Number of DNA copies of a given gene Control of RNA polymerase rate mRNA lifetime/stability Number of available ribosomes for translation Rate of amino acid attachment of peptide Protein lifetime/stability How can we control the amount and timing of protein production?
Background image of page 4
Recap Nucleosome Formation Cysteine Methylation/ CpG Islands Histone code Hypothesis Annual Review of Pharmacology and Toxicology Vol. 45: 495-
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Recap http://cnx.org/content/m11416/latest/
Background image of page 6
From classroom to laboratory You understand basics of cells, organelles, transcription, translation and gene regulation. How can you use this knowledge to advance scientific knowledge? How do you answer ‘novel’ scientific questions– TOOLS? Think like a scientist………
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
A hypothetical scenario… A new virus X has emerged that is causing havoc in the world. As a cell and molecular biologist, you are appointed by CDC to find out more about the virus. How will you proceed?
Background image of page 8
need to understand its genes and proteins. Understand the genome of the virus Compare the genome with known viruses How are the host proteins affected by the virus? Study the interaction of virus proteins with host proteins
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 10
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 12/09/2011 for the course BIO 230 taught by Professor .. during the Fall '10 term at Purdue University.

Page1 / 40

From%20Genomics%20to%20Proteomics-%20Bio%20230-%2011-07-2011...

This preview shows document pages 1 - 10. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online