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Unformatted text preview: – Some IRs also Glucose transporters GLUT4 move to plasma membrane where they… – …increase glucose influx – IR substrates increase glycogen, lipid, and protein biosynthesis (energy storage) – Long term: transcription of genes, synthesis of proteins involved in amino acid influx Insulin inhibits Hormone-sensitive lipase, an enzyme which degrades lipids, resulting in net lipid storage Type 1 Diabetes: – Too little insulin due to damaged beta cells in pancreas, autoimmune – Increased glucagon – Increased glucose production by liver, decreased utilization – Hyperglycemia (excessive glucose in blood) – Increased production of ketoacids (protein degradation products) unchecked by insulin – Increased urine output – Glucose control assessed by glycated hemoglobin Type 2 Diabetes: – Insulin is relatively normal – Tissue response to insulin is impaired resulting in increased blood glucose – Associated with age and obesity...
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This note was uploaded on 04/06/2008 for the course BMVS 4064 taught by Professor Dr.lee during the Spring '08 term at Virginia Tech.
- Spring '08