_ALLEN__Prostaglandin_Lectures

_ALLEN__Prostaglandin_Lectures - Eicosinoid Metabolism...

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Eicosinoid Metabolism BCH4024 Charles M. Allen Office: R3-252 Phone: 392-3366 email: callen@ufl.edu
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Lipid Anabolism (Biosynthesis) Fatty acids Cholesterol ACETYL CoA Prostaglandins, Thromboxanes Leucotrienes Phospholipids Triglycerides Sphingolipids HMG CoA Steroids Bile Acids Vit D
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Common Unsaturated Fatty Acids ϖ 9 ϖ 9 ϖ 6 ϖ 3 ϖ 6
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Classification and Dietary Sources of the Fatty Acids Animals do not have enzymes to introduce double bonds beyond position C 9 in the fatty acid.
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Introduction of Double Bonds into Fatty Acids The C 16 and C 18 saturated fatty acids are oxidized in the 9-10 position by a desaturase. C 16 –CoA 9 -C 16 C 18 –CoA 9 -C 18 Desaturase Stearyl CoA + 3H + + O 2 +NADH Oleoyl CoA + 2 H 2 O + NAD + C 18 –CoA 9 -C 18 CoA The desaturase includes a mini electron transport system containing a non- heme iron protein, a cytochrome and a reductase.
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Biosynthesis of Polyunsaturated Fatty Acids Plants insert double bonds beyond position 9 i.e. at positions 12 and 15. Since animals cannot synthesize polyunsaturated fatty acids with double bonds in position 12 and 15, they must take such fatty acids in via their diet. Then they convert these fatty acids into precursors of important products such as prostaglandins, leucotrienes, and tromboxanes. Plant Polyunsaturated Fatty Acids Used By Animals α - Linoleic acid α - Linolenic acid γ - Linoleic acid 9 9 9 6 15 12 12 12
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Animals then use desaturases like the ones just discussed to introduce additional double bonds at position 5 and 6.
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Animals use elongases to add C 2 units from either acetyl CoA or malonyl CoA , none of which uses ACP or fatty acid synthase.
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This note was uploaded on 12/09/2011 for the course BCH 4024 taught by Professor Allison during the Spring '08 term at University of Florida.

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_ALLEN__Prostaglandin_Lectures - Eicosinoid Metabolism...

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