L-5 - PROTEIN STRUCTURE 1) Primary structure (1°) —the...

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Unformatted text preview: PROTEIN STRUCTURE 1) Primary structure (1°) —the defined amino acid sequence. -i.e., the covalent backbone. (What about disulfide bonds?) -the primary structure determines the pattern of higher levels of structure -main bonaing force: covalent The central covalent linkage in proteins and in the primary structure is the peptide bond. 77am {5 very fwl's’l'ina. V R9507. ace : 2) 3,719 C —' O LOKJ all} {Tyre to“ {'Le CWAa-ny) grog/a {5 )0 “99" fjsA‘K mar)“; see» :» Lei-he; w 3)J617495 A) We Lana! at: hue is Izori‘el‘ . . . '9 «do ,nr'l'ia’ claret-s 3) P’Znal‘ an re 01‘ feftliJe long? Looking 8499-0711 4’) “773. n: ” covawcfour X50). cfs ‘Fepi'd? 20M: {[3 06vth 2w)- ?rf WWCA [85$ Cowman ‘5 o1c'é’rt, assoc;d£9¢, 2 Fr?) [[46 0 "K . H\ zf'é‘—N/£Q\ ’ /C\ I K . H K D‘Aealrz’ aha/e! flax he s. 3 aha/9319A?!» C73 2) Secondary structure (2°) Refers to a regular, recurring arrangement in space along one dimension. Right—handed °<—helix very common very stable examples: fibrous: X—keratln globular: myoglobin minimal distortion of bond lengths and angles and planarity of peptide bond. O I M [Jim‘- Wander 07L What) BCiXI Pff‘ [Lu/3, .- “I. rfje per residue radius of" ZQ/I’X. h — Amino terminus 0 Hydrogen Oxygen I; .. (a) (c) David L. Nelson and Michael M. Cox. Figure 4.4 LEHNINGER PRINCIPLES OF BIOCHEMISTRY, Fourth Edition. T-012 © 2005 by W. H. Freeman and Company. Ofker Lexus: ' @ 3,0 lelix 1 '3 ’m;l\0 an‘J “‘3’. "es 9r). é "0 00° " C ’ ac /‘°\, ‘ 41/ N j #ar mos} CD, a“) w 3‘41)er sierfc firing/8M5 JIM/é @ COLLAGEN HELIX Collagen is fhe mosf abundanf profein in mammals . If is a fibrous profein fhaf is wafer insoluble. There are of leasf eleven differenf fypes of collagen found in humans. ‘ The mosf common is Type I‘ ‘ Abouf 96% of fhe collagen sequence is: -GLY—X—Y— where X is offen proline and Y is offen hydroxyproline. ‘71”: kfi'f-Aadpl ,(e ’1'“) ff/J’aJJ (can! lbw} 1000 am.“ an}: are wound o'a'l'o a rlylf-Adadel hwy/e Ive/3 x ( some fine 3 u lle/ fro/no col/gel) role 0 '( ff»; - 4"L7J/OK7/D/‘0lo'ne: «Porn-ain't» 0“ 4’17J/oV/rc/{ne '. ...
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L-5 - PROTEIN STRUCTURE 1) Primary structure (1°) —the...

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