TCA - CITRIC ACID CYCLE CITRIC = TCA CYCLE = KREBS CYCLE

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CITRIC ACID CYCLE CITRIC ACID CYCLE = TCA CYCLE = KREBS CYCLE = TCA CYCLE = KREBS CYCLE                                TCA = tricarboxylic acid cycle Definition: Definition:  -- Acetate in the form of  acetyl-CoA , is derived from pyruvate and other metabolites, and is  oxidized oxidized  to CO 2  in the  citric acid cycle .
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************************************************************  One high energy compound is produced for each cycle.  The electrons from the TCA cycle are made available to an  electron  ransport chain   in the form of three NADH and one FADH and ultimately energy is provided for oxidative phosphorylation. ************************************************************
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******************************************* The citric acid cycle is  central to all respiratory oxidation , oxidizing acetyl-CoA from glucose, lipid and  protein catabolism in aerobic  respiration to maximize energy gain. The cycle also supplies some precursors  for biosynthesis. All enzymes are in the mitochondrial matrix or inner mitochondrial membrane ********************************************
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The  three stages three stages    of cellular respiration: Stage 1 .   Acetyl CoA production  -  from glucose, fatty acids and amino acids Stage 2 .  Acetyl CoA oxidation = TCA Cycle   = yielding reduced electron carriers Stage 3 Electron transport and oxidative phosphorylation   - oxidation of these carriers and production of ATP ***************************************************
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      Many catabolic pathways yield Many catabolic pathways yield               acetyl CoA for the TCA cycle acetyl CoA for the TCA cycle          glycogen glycogen                         glucose glucose                             lactate lactate               pyruvate pyruvate     fatty acids fatty acids                 amino acids amino acids        Acetyl-CoA Acetyl-CoA                              TCA TCA    (Note: aa more than one entry point)
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Acetyl CoA Acetyl CoA      HS-CoA       Space filled Acetyl A high energy bond
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0- Conversion of pyruvate to acetyl-CoA -- A major Stage 1 setup  Enzyme =   pyruvate dehydrogenase complex pyruvate dehydrogenase complex         Location  =  mitochondrial matrix CH 3           CH 3 C=O + NAD + + HS-CoA  C=O +NADH+CO 2 COO -        S-CoA   Pyruvate       Acetyl-CoA   (A high energy  compound)
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Irreversible     -- irreversible means acetyl-CoA cannot be converted backward to pyruvate; hence “fat cannot be converted to carbohydrate”
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  Complex of 2.5 x 10 6  Da, including multiple  copies of three enzymes
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This note was uploaded on 12/09/2011 for the course BCH 4024 taught by Professor Allison during the Spring '08 term at University of Florida.

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TCA - CITRIC ACID CYCLE CITRIC = TCA CYCLE = KREBS CYCLE

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