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1pp Biotin 11 - BIOTIN BIOTIN Spring 11 Reading Assignment...

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BIOTIN Spring 11 Reading Assignment 342-348
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Biotin Deficiency Raw egg white diet E lk d “ hit i j – Egg yolk cured “egg white injury” Avidin in raw egg whites • Binds to avidin Binds to avidin Resistant to pancreatic enzymes – Dermatitis hair loss neurological abnormalities – Dermatitis, hair loss, neurological abnormalities
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Fig. 9-19, p. 343
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Biotin: Structure Fig. 9-20, p. 343
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i i d Biotin: Food Sources • Richest sources E lk –Egg yolk –Peanut butter • Intestinal microflora
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Biotin: Absorption • Dietary biotin is mainly protein- bound • Biotinidase in secretions of ti ti pancreatic secretions –hydrolysis of biotin-protein
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Biotin: Absorption • Active transport- carrier mediated uptake –Sodium-dependent multivitamin transporter (SMVT) • transports lipoic acid & pantothenic transports lipoic acid & pantothenic acid P i diff i l d • Passive diffusion: large doses
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Absorption of Bacterially Absorption of Bacterially Synthesized (colon) Biotin • Bacteria synthesize biotin in colon. acte a sy t es e b ot co o • Unknown how much is absorbed S d h h l • Studies have shown colonic epithelial cells capable of absorbing biotin
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Biotin: Transport • ~80% free i b d • Protein-bound –albumin albumin β -globulin –biotinidase
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f i i i i Transport of Biotin into Liver • Sodium dependent multivitamin transporter (SMVT) transports transporter (SMVT) transports biotin into liver cells
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