1pp Biotin 11 - BIOTIN BIOTIN Spring 11 Reading Assignment...

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BIOTIN Spring 11 Reading Assignment 342-348
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iotin Deficiency Biotin Deficiency Raw egg white diet – Egg yolk cured “egg white injury” • Avidin in raw egg whites inds to avidin • Binds to avidin • Resistant to pancreatic enzymes ermatitis hair loss neurological abnormalities – Dermatitis, hair loss, neurological abnormalities
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Fig. 9-19, p. 343
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iotin: Structure Biotin: Structure Fig. 9-20, p. 343
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Biotin: Food Sources • Richest sources –Egg yolk –Peanut butter • Intestinal microflora
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iotin: Absorption Biotin: Absorption • Dietary biotin is mainly protein- ound bound • Biotinidase in secretions of pancreatic secretions –hydrolysis of biotin-protein
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Biotin: Absorption • Active transport- carrier mediated ptake uptake –Sodium-dependent multivitamin transporter (SMVT) ansports lipoic acid & pantothenic transports lipoic acid & pantothenic acid • Passive diffusion: large doses
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bsorption of Bacterially Absorption of Bacterially Synthesized (colon) Biotin •B acteria synthesize biotin in colon. acte a sy t es e b ot co o • Unknown how much is absorbed • Studies have shown colonic epithelial cells capable of absorbing biotin
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Biotin: Transport • ~80% free •Protein-bound lbumin albumin β -globulin –biotinidase
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Transport of Biotin into Liver • Sodium dependent multivitamin ansporter (SMVT) transports transporter (SMVT) transports biotin into liver cells
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Biotin Excretion • Urinary excretion • Intact biotin ~50% of excreted iotin catabolites Biotin catabolites
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Fig. 9-26, p. 347
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Table 9-2, p. 344
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Fig. 9-21, p. 344
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Biotin: Function • Biotin-dependent carboxylases talyze the incorporation of –catalyze the incorporation of bicarbonate into a substrate as a rboxyl group carboxyl group
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Attachment of the biotin to the apocarboxylase Fig. 9-22, p. 345 Catalyzed by holocarboxylase synthetase
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Biotin: Functions • Acetyl CoA carboxylase • Catalyze the incorporation of bicarbonate into acetyl Co A to form malonyl CoA
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Acetyl CoA Carboxylase ceytl CoA + HCO + ATP alonyl CoA Aceytl CoA + HCO + ATP Malonyl CoA Fatty Acid Synthesis Complex
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ractice Question Practice Question A patient with severe biotin deficiency has py abnormal fatty acid synthesis. Select the correct name of the enzyme(s) for which iotin functions as a coenzyme in the fatty biotin functions as a coenzyme in the fatty acid biosynthesis pathway. (a) acetyl CoA carboxylase b) pyruvate carboxylase ()p y y (c) methyl malonyl CoA mutase (d) β -methyl crotonyl CoA carboxlase (e) all of the above
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ractice Question Practice Question A patient with severe biotin deficiency has py abnormal fatty acid synthesis. Select the correct name of the enzyme(s) for which iotin functions as a coenzyme in the fatty biotin functions as a coenzyme in the fatty acid biosynthesis pathway.
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1pp Biotin 11 - BIOTIN BIOTIN Spring 11 Reading Assignment...

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