1pp Chromium 2011 _Compatibility Mode_

1pp Chromium 2011 _Compatibility Mode_ - Chromium Chromium...

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hromium Chromium 2011 ource: WebElements "Source: WebElements [http://www.webelements.com/]"
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hromium: Discovery of Chromium: Discovery of Essentiality Time Line of Discovery 959 957 967 977 1959 1957-1967 1977 Schwarz and Mertz discover a chromium compound restored Malnourished children with impaired glucose Female on TPN who developed signs of p glucose tolerance in animals by enhancing e action of insulin pg tolerance given chromium = proved glucose g diabetes given chromium = mptoms the action of insulin improved glucose tolerance symptoms ameliorated
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Chromium: Chemistry hromium is a transition element Chromium is a transition element – Can occur in a number of valence states + and 6+ most common • 3+ and 6+ most common •C r 6+ is strong oxidizing agent from industrial sources •Cr 6+ consumed in small quantities – reduced to Cr 3+ in stomach Cr 3+ = Most important form in humans
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hromium: Excellent Sources Chromium: Excellent Sources Brewer’s Yeast Some brands of beer contain sig amounts
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hromium: Other Sources Chromium: Other Sources t Meat hole Grain Poultry Nuts Whole Grain Cereals
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hromium: Food Processing Chromium: Food Processing efining & milling decreases Cr content Refining & milling decreases Cr content –Ex: has less Cr an than White sugar Brown sugar Molasses • Stainless steel + acid foods increases Cr
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Chromium: Absorption • Intestinal absorption rimary absorption: jejunum Primary absorption: jejunum – May be carrier mediated • Rate of absorption: 1-3% – Form influences absorption
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Chromium: Absorption Enhancement itamin C increases absorption Vitamin C increases absorption • Ligands chelate Cr to maintain solubility • Solubility increases absorption •Ex: Picolinate as a ligand: •helps maintain solubility •is relatively stable •is lipophilic
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organic Cr in neutral or alkaline Chromium: Absorption Inhibition Inorganic Cr in neutral or alkaline environment reacts with OH - ions • Olation = high MW cmpd of Cr + OH - • Cr precipitation = decreased absorption •Ex: Antacids decrease lood and tissue Cr blood and tissue Cr
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hromium: Transport Chromium: Transport rimarily bound to transferrin Primarily bound to transferrin •M a y bind to albumin if transferrin unavailable • High Cr concentrations - Globulins/lipoproteins • Body pool: 4-6 mg transferrin
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hromium: Function Chromium: Function otentiates the action of insulin to • Potentiates the action of insulin to improve glucose tolerance. • Mechanism still under investigation.
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1pp Chromium 2011 _Compatibility Mode_ - Chromium Chromium...

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