1pp Copper Lecture 11

1pp Copper Lecture 11 - Copper Copper 2011 "Source:...

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opper Copper 2011 " ource: WebElements Source: WebElements [http://www.webelements.com/]"
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Copper: Forms • Cu is found in the body in two xidation states: oxidation states: + + Cu 1+ Cu 2+ Cuprous State Cupric State
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opper: Food Sources Copper: Food Sources Best sources Table 12-5, p. 446
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Copper: Absorption • Exact mechanism not yet discovered • 25 - 50% absorbed (1-2 mg/day) – Deficiency: absorption – Excess: absorption I tract GI tract – Stomach Jejunum j
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Copper: Factors Affecting Absorption Enhancers Inhibitors mino acids hytate Amino acids Phytate histidine Zinc methionine/cysteine Iron Glutathione Molybdenum Organic acids Calcium/phosphorus trate itamin C citrate Vitamin C
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Nutrition Reviews 68(3): 133-147
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Copper: Transport • Portal circulation bumin albumin α -macroglobulin • Liver – Ceruloplasmin (CP) 0 5% plasma Cu • 60-95% plasma Cu – 6 copper/1 Cp • Cu incorporated into CP in liver • CP – CP is major pool of Cu in plasma
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opper: Storage and Excretion Copper: Storage and Excretion otal body copper Total body copper 75-150 mg –L ive r 15% – Muscles 40% • Fecal copper 97% Losses • Sloughed cells • Bile •Unabsorbed dietary copper
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Copper: Functions Metalloenzyme: 1. Ceruloplasmin (Cp) ¾ The primary function of the enzyme is to mediate transport of stored Fe p. 451a
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Copper: Ceruloplasmin –Anem ia • Fe must be oxidized to Fe +3 to bind to transferrin • Cp oxidizes Fe (ferroxidase) allowing it to be: – transported from storage to tissues • Another ferroxidase is important in iron metabolism as well.
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This note was uploaded on 12/09/2011 for the course HUN 4445 taught by Professor Sitren during the Spring '08 term at University of Florida.

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1pp Copper Lecture 11 - Copper Copper 2011 "Source:...

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