1pp Riboflavin 2011

1pp Riboflavin 2011 - Rib oflavin pring 2011 Spring 2011...

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Unformatted text preview: Rib oflavin pring 2011 Spring 2011 History: Old Yellow Enzyme Warburg and Christian discovered physiological function of riboflavin coenzymes nzyme- AD complex referred to a old enzyme FAD complex referred to a old yellow eznyme due to bright yellow color Riboflavin Function Precursor of Flavin Coenzymes: FMN and FAD Coe y es a d Major Dietary Riboflavin Sources: US Meat, poultry, and fish 1 serving beef provides 16% RDA serving fish provides up to 30% of RDA 1 serving fish provides up to 30% of RDA ilk and dairy products Milk and dairy products 1 quart milk = 100% RDA for adults Enriched grain products iboflavin Stability Riboflavin Stability Unstable to sunlight ilk Milk Glass containers 70% loss of riboflavin in 4 hrs Opaque containers Less riboflavin lost Rib oflavin Absorption Absorption Dietary sources largely in form of coenzyme derivatives- ust by hydrolyzed before absorbed must by hydrolyzed before absorbed Upper small intestine by specialized mechanism involving phosphorylation-dephosphorylation rather than by passive iffusion diffusion Process is sodium dependent and involves an ATPase active transport system that can be saturated Rib oflavin Absorption Absorption Maximum transport capacity is ~25 mg elaying intestinal transit time of food may result in increase Delaying intestinal transit time of food may result in increase in amount absorbed Consumption of food with riboflavin increases absorption Bile acids increase absorption ransport and Excretion Transport and Excretion Albumin: major transport protein Immunoglobulins IgA, IgG, and IgM Cellular uptake by riboflavin carrier mediated Very little riboflavin stored rinary excretion- rimarily intact Urinary excretion primarily intact riboflavin molecule not FAD FMN Riboflavin Function Coenzymes widely distributed and talyze numerous oxidation duction catalyze numerous oxidation-reduction...
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1pp Riboflavin 2011 - Rib oflavin pring 2011 Spring 2011...

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