3pp HUN4221.Iron.Lecture1.Spring

3pp - Iron Hun4221 Spring 2011 Lecture#1 Mitchell D Knutson PhD [email protected] Outline of Iron Lectures Lecture 1 2 Topics I II III A Bonemarrow

Info iconThis preview shows pages 1–4. Sign up to view the full content.

View Full Document Right Arrow Icon
3/29/2011 1 Iron Hun4221 Spring 2011 Lecture #1 Mitchell D. Knutson, PhD [email protected] Outline of Iron Lectures Lecture Topics 1 I. General introduction to iron II. Dietary iron and iron absorption III. Systemic iron metabolism A. Bone marrow B. Reticuloendothelial system (RES) C. Liver IV. Regulation of whole body iron metabolism 2 V. Regulation of cellular iron metabolism VI. Biochemical functions of iron VII. Clinical assessment of iron status VIII. Iron deficiency X. Iron overload Iron is an essential transition metal element electrolyte element trace element; biochemical essentiality defined “organic” element trace element; biochemical essentiality poorly defined Merchant SS et al., Biochimica et Biophysica Acta, 2006 Elements associated with life
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
3/29/2011 2 Aqueous solution chemistry of iron Fe 2+ Fe 3+ ferrous ferric reduced oxidized 0 pH 2+ 3+ 1 2 3 4 5 6 7 Gastric juice Lemon juice Cola Red wine Black coffee Saliva Plasma Fe(H 2 0) 6 Fe(H 2 0) 6 Fe(0H) 2 ppt Fe(0H) 3 ppt Location and functions of iron in the body Compartment Iron (g) % of Total Hemoglobin 2.0 65 Myoglobin 0.3 10 Heme Enzymes 0.06 2 Binding and transport of O 2 Electron transfer Total body iron content: ~2.3 g ~3.8 g Nonheme Enzymes NADH dehydrogenase succinate dehydrogenase 0.03 1 Intracellular Labile Fe 0.04 (?) 1 Transferrin 0.0023 0.001 Ferritin/Hemosiderin 0.75 25 Intercellular Fe transport Storage Oxidative metabolism Gene regulation 2/3 of body iron is in hemoglobin in RBCs
Background image of page 2
3/29/2011 3 new erythrocytes senescent erythrocytes circulating erythrocytes Liver Overview of iron metabolism Bone marrow Reticuloendothelial System (RES) Duodenum
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 4
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 12/09/2011 for the course HUN 4445 taught by Professor Sitren during the Spring '08 term at University of Florida.

Page1 / 15

3pp - Iron Hun4221 Spring 2011 Lecture#1 Mitchell D Knutson PhD [email protected] Outline of Iron Lectures Lecture 1 2 Topics I II III A Bonemarrow

This preview shows document pages 1 - 4. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online