3pp HUN4221.Iron.Lecture2.Spring

3pp HUN4221.Iron.Lecture2.Spring - 3/29/2011 HUN 4813C (3...

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3/29/2011 1 HUN 4813C (3 credits, (3 credits, Fall 2011 Fall 2011) Laboratory Techniques in Molecular Nutrition Thinking about going to graduate school? Interested in gaining laboratory research experience? Format: Two, 50-minute lectures, and one, 3-hour lab per week. Prerequisites: Grades of “B” or higher in CHM2210 & CHM2211. BCH3025 and 4024 preferred. Enrollment: Limited to 16 students—so hurry! Schedule: TBA If so, consider taking HUN 4813C! To learn more, contact Dr. Mitchell Knutson at: mknutson@ufl.edu or at FSHN building (Room 459). Interested in learning cutting-edge techniques in molecular biology as they relate to research in nutritional sciences? Iron Hun4221 Spring 2011 Lecture #2 Mitchell D. Knutson, PhD mknutson@ufl.edu Outline of Iron Lectures Lecture Topics 1 I. General introduction to iron II. Dietary iron and iron absorption III. Systemic iron metabolism A. Bone marrow B. Reticuloendothelial system (RES) C. Liver IV. Regulation of whole body iron metabolism 2 V. Regulation of cellular iron metabolism VI. Biochemical functions of iron VII. Clinical assessment of iron status VIII. Iron deficiency IX. Iron overload
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3/29/2011 2 V. Regulation of cellular iron metabolism 1) We learned in the last lecture how the body “knows” how much iron to absorb from the diet. 2) How do individual cells “know” how much iron to take up? V. Regulation of cellular iron metabolism Central dogma of molecular biology
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3/29/2011 3 Ferritin: iron storage protein Da mRNA contains an IRE in its 5’UTR ferritin mRNA transferrin receptor mRNA Translation blocked mRNA is stable and translated LOW IRON Iron regulatory protein IRP Post-transcriptional regulation of ferritin and transferrin receptor NO FERRITIN MADE TRANSFERRIN RECEPTOR MADE HIGH IRON mRNA translated FERRITIN MADE Fe mRNA is unstable and degraded NO TRANSFERRIN RECEPTOR MADE Fe The IRE/IRP regulatory system
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3/29/2011 4 VI. Biochemical functions of Iron Lecture Topics 2 V. Regulation of cellular iron metabolism VI. Biochemical functions of iron VII. Clinical assessment of iron status VIII. Iron deficiency IX. Iron overload VI. Biochemical functions of iron The essential nature of iron derives mainly from its facile ability to change between Fe 2+ and Fe 3+ oxidation states.
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3pp HUN4221.Iron.Lecture2.Spring - 3/29/2011 HUN 4813C (3...

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