6pp HUN4221.Iron.Lecture1.Spring

6pp HUN4221.Iron.Lecture1.Spring - 3/29/2011 Iron Outline...

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3/29/2011 1 Iron Hun4221 Spring 2011 Lecture #1 Mitchell D. Knutson, PhD mknutson@ufl.edu Outline of Iron Lectures Lecture Topics 1 I. General introduction to iron II. Dietary iron and iron absorption III. Systemic iron metabolism A. Bone marrow B. Reticuloendothelial system (RES) C. Liver IV. Regulation of whole body iron metabolism 2 V. Regulation of cellular iron metabolism VI. Biochemical functions of iron VII. Clinical assessment of iron status VIII. Iron deficiency X. Iron overload Iron is an essential transition metal element electrolyte element trace element; biochemical essentiality defined “organic” element trace element; biochemical essentiality poorly defined Merchant SS et al., Biochimica et Biophysica Acta, 2006 Elements associated with life Aqueous solution chemistry of iron Fe 2+ Fe 3+ ferrous ferric reduced oxidized 0 pH 2+ 3+ 0 1 2 3 4 5 6 7 Gastric juice Lemon juice Cola Red wine Black coffee Saliva Plasma Fe(H 2 0) 6 Fe(H 2 0) 6 Fe(0H) 2 ppt Fe(0H) 3 ppt Location and functions of iron in the body Compartment Iron (g) % of Total Hemoglobin 2.0 65 Myoglobin 0.3 10 Heme Enzymes Cytochromes a, b, c 0.06 2 Binding and transport of O 2 Electron transfer Total body iron content: ~2.3 g ~3.8 g Nonheme Enzymes NADH dehydrogenase succinate dehydrogenase 0.03 1 Intracellular Labile Fe 0.04 (?) 1 Transferrin 0.0023 0.001 Ferritin/Hemosiderin 0.75 25 Intercellular Fe transport Storage Oxidative metabolism Gene regulation 2/3 of body iron is in hemoglobin in RBCs
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3/29/2011 2 new erythrocytes senescent erythrocytes circulating erythrocytes Liver Overview of iron metabolism
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6pp HUN4221.Iron.Lecture1.Spring - 3/29/2011 Iron Outline...

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