Cu 3 pp - Copper 2011 "Source: WebElements...

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Copper 2011 "Source: WebElements [http://www.webelements.com/]" Copper: Forms • Cu is found in the body in two oxidation states: Cu 1+ Cu 2+ Cuprous State Cupric State Copper: Food Sources Best sources Table 12-5, p. 446
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Copper: Absorption • Exact mechanism not yet discovered • 25 - 50% absorbed (1-2 mg/day) – Deficiency: absorption – Excess: absorption • GI tract – Stomach – Jejunum Copper: Factors Affecting Absorption Enhancers Inhibitors Amino acids Phytate histidin Zin histidine Zinc methionine/cysteine Iron Glutathione Molybdenum Organic acids Calcium/phosphorus citrate Vitamin C Nutrition Reviews 68(3): 133-147
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Copper: Transport • Portal circulation – albumin α -macroglobulin •L i v e r – Ceruloplasmin (CP) • 60-95% plasma Cu – 6 copper/1 Cp • Cu incorporated into CP in liver • CP – Cu is major pool of Cu in plasma Copper: Storage and Excretion Total body copper 75-150 mg –L ive r 15% – Muscles 40% • Fecal copper
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Copper: Functions Metalloenzyme: 1. Ceruloplasmin (Cp) The primary function of the enzyme is to mediate transport of stored Fe p. 451a – Anemia • Fe must be oxidized to Fe +3 to bind to transferrin Copper: Ceruloplasmin • Cp oxidizes Fe (ferroxidase) allowing it to be:
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This note was uploaded on 12/09/2011 for the course HUN 4445 taught by Professor Sitren during the Spring '08 term at University of Florida.

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Cu 3 pp - Copper 2011 "Source: WebElements...

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