HUN 4221 Ascorbate 2011 3-pg

HUN 4221 Ascorbate 2011 3-pg - Dr Lynn Bailey Nutritional...

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UF Professor 30 years. Married to my colleague. Son a freshman at UF. Favorite thing about my job is teaching HUN 4221. Dr. Lynn Bailey Nutritional Sciences University Professor Gainesville, FL Photography Vitamin C Reading Assignment pgs 311-322 History • Military diets 17 th -19 th centuries –deaths of millions of sailors due to scurvy • First paper written by Lind in 1753 linked missing food component to disease • Early 1800s lime juice part rations Britain – Origin of term “limeys” for British sailors
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In US large number of deaths due to scurvy in 1800s Vitamin C named ascorbic acid Ability to cure and prevent scurvy Research related to chemistry of vitamin C 2 Nobel Prizes in medicine and chemistry Szent-Gyorgyi and Haworth Vitamin C: Synthesis • Humans, non-human primates, guinea pigs, Indian fruit bats, some types of birds fish – Lost ability to express gene for gulonolactone oxidase – Require dietary sources
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Many animals synthesize ascorbic acid from glucose – Gulonolactone oxidase • catalizes the oxidation of L- gulonolactone to L-2- ketogulonolactone – isomerizes to ascorbic acid Vitamin C: Synthesis Vitamin C: Food Sources •Plant sources –Fruits •Citrus fruits, tomatoes •Cantaloupe, kiwi, strawberries –Vegetables • Broccoli • Red pepper, spinach • Brussels sprouts, asparagus • Fortified foods –Breakfast cereals Vitamin C: Food Sources
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Vitamin C Degradation in Food • Ascorbic acid easily oxidized and destroyed –raw foods more ascorbate-dense •Oxygen, light, heat –Fe & Cu promote oxidation –hydrolytic opening of lactone ring to 2,3 diketogulonic acid- inactive Vitamin C Degradation in Food Vitamin C: Deficiency •Scurvy – Low fruit and vegetable intake •Fatigue •Muscle cramps
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Vitamin C: Deficiency • Anorexia • Bruising, bleeding gums • Anemia • Delayed wound healing Vitamin C: Deficiency • Infants develop deficiency quickly due to rapid growth rate • Irritability • Anorexia • Growth failure • Joint tenderness • Anemia Vitamin C: Deficiency • Defective collagen –Bone matrix • Primarily collagen • Impaired calcium/phosphorus assimilation • Bones: thin & weak • Pain with movement – Scorbutic rosary
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Scorbutic Rosary X-ray: Scorbutic Rosary Vitamin C: Deficiency- Abnormal Bruising and Bleeding Under Skin Vitamin C: Deficiency: Abnormal Connective Tissue and Fragile Capillaries
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Vitamin C: Deficiency: Pinpoint Hemorrhages of Skin- Bleeding Into Hair Follicles Vitamin C: Absorption • Active transport – Sodium vitamin C cotransporter (SVCT)- transports vit C into enterocyte – Two isoforms of this transporter • SVCT1 predominately involved in intestinal absorption and kidney reabsorption • SVCT2 primarily involved in uptake in metabolically active tissues • Passive diffusion – pharmacological doses
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