15 - Cancer Therapy - WJD 2011

15 - Cancer Therapy - WJD 2011 - 3/29/2011 Prevent or...

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3/29/2011 1 HUN4445 March 29, 2011 Discuss the major types of cancer therapy Describe the impact of cancer therapy on nutritional status of the cancer patient Discuss the nutritional management of the cancer patient Prevent or reverse nutrient deficiencies Preserve lean body mass Minimize nutrition-related side effects Minimize nutrition related side effects Maximize quality of life Chemotherapy Radiation Therapy Immunotherapy Surgery Bone marrow or peripheral stem cell transplant Systemic therapy – affects normal and cancerous cells Acts on most actively dividing cells Cancer cells Bone marrow Hair follicles GI tract http://cancernet.nci.gov
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3/29/2011 2 Cell cycle-specific agents Antimetabolites Mitotic inhibitors Cell cycle-nonspecific agents Aklylating agents Antitumor antibiotics Hormonal agents Immunotherapy In use since 1948 Prevent DNA and RNA synthesis Inhibit purine synthesis Inhibit enzymes involved in DNA synthesis Inhibit RNA synthesis Suppress proliferation in mitotically active tissue Eg. Flurouracil, Methotrexate, Asparaginase Interferes with mitotic spindle formation during metaphase Vincristine, Paclitaxel, Etoposide ± Generate O 2 free radicals; cause breaks in DNA Bind to nucleic acids; disrupt DNA helix Doxorubicin (Adriamycin)
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3/29/2011 3 Block hormones that stimulate growth i.e. Glucocorticoids (prednisone, dexamethasone) Break down tissue, cause loss of protein, calcium, potassium Antiandrogens (flutamide) Antiestrogens (tamoxifen) Progestins (megestrol) Gonadotropin-releasing hormone analog (leuprolide) Increased appetite Obesity Hyperglycemia Hypertension Impaired wound healing Loss of calcium from bone Protein catabolism Stimulation of natural killer (NK) cells Interferon alpha Interleukin Epoetin alpha Filgastim
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This note was uploaded on 12/09/2011 for the course HUN 4445 taught by Professor Sitren during the Spring '08 term at University of Florida.

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15 - Cancer Therapy - WJD 2011 - 3/29/2011 Prevent or...

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