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18 - Drug Nutrient Interactions -WJD 2011 handouts

18 - Drug Nutrient Interactions -WJD 2011 handouts - Drug...

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Drug, Nutrient and Food Interactions HUN4445 April 14, 2011 Discuss pharmacotherapy as it relates to nutrition Identify ways that foods affect drugs and drugs affect nutritional status Describe some common drug-nutrient interactions Patients shall be educated how to safely use medications Food-drug interactions is one of 12 parameters Medications achieve intended effects Patients don’t discontinue drugs Need for additional medication decreased Adverse side effects avoided Optimal nutritional status preserved Disease complications reversed Cost of health care is reduced Less professional liability Pharmacodynamic interactions Effects on the pharmacologic action of the drug Binding to receptor or enzyme Pharmacokinetic interactions Effects on movement of the drug into, around or out of the body Absorption, distribution, metabolism excretion Foods and nutrients can affect drug kinetics Drugs can affect nutritional status
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Genetics Malnutrition Polypharmacy Use of alcohol, herbal supplements Body weight Body composition Age Gender General physical condition Oral IV Rectal Intramuscular (IM) Topical Subcutaneous Sublingual Inhalants First pass phenomenon concentration Half-life Minimum effective concentration (MEC) Minimum toxic concentration (MTC) Desired therapeutic range on of drug desired therapeutic range onset termination Time MTC MEC Plasma concentratio } “narrow” window “normal” window MTC MTC MEC MEC digoxin/digitalis/Lanoxin other drugs
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