Class 15 Parenteral part 2 2011

Class 15 Parenteral part 2 2011 - HUN4445 Nutrients in PN...

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HUN4445 Nutrients in PN Dextrose concentration: 5 to 70% Usual PN: ~25% Fluid-restricted or pts with higher needs: 35% Respiratory insufficiency/diabetes: use less? Peripheral administration: 5 to 10% Effects of excessive carbohydrate Hyperglycemia (high blood sugar) Glucosuria (glucose in urine) Hepatic steatosis (fatty liver) Excessive CO 2 production respiratory insufficiency Cholestasis (flow of bile blocked/decreased) Amino Acids Crystalline L- amino acids Essential & non-essential amino acids Disease-specific AA solutions Concentrations: 3% 3.5% 5% 7% 8.5% 10% 15% Fat emulsion 2 to 4% kcals from linoleic acid to prevent EFA deficiency Maximum: 2.0 to 2.5 g fat/kg BW/d <60% kcals from fat septic pts: 1 g/kg BW/d (maximum) LCFA may suppress immune system Impair neutrophil function Decrease endotoxin clearance Decreased complement synthesis No >1 g/kg limit for pts with immunological problems
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This note was uploaded on 12/09/2011 for the course HUN 4445 taught by Professor Sitren during the Spring '08 term at University of Florida.

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Class 15 Parenteral part 2 2011 - HUN4445 Nutrients in PN...

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