Class 20 Drug Nutrient Interactions 2011

Class 20 Drug Nutrient Interactions 2011 - Drug-Nutrient...

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Drug-Nutrient Interactions Objectives: Discuss pharmacotherapy as it relates to nutrition Identify ways that foods affect drugs and drugs affect nutritional status Describe some common drug-nutrient interactions Benefits of minimizing interactions Medications achieve intended effects Patients don’t discontinue drugs Need for additional medication decreased Adverse side effects avoided Optimal nutritional status preserved Disease complications reversed Cost of health care is reduced Less professional liability Pharmacodynamic interactions Effects on the pharmacologic action of the drug Binding to receptor or enzyme Pharmacokinetic interactions Effects on movement of the drug into, around or out of the body Risk factors for Interactions Genetics Acetylation of isoniazid Malnutrition Polypharmacy Use of alcohol, supplements Factors that modify drug effects Routes of drug administration Oral, IV, Rectal, Intramuscular IM, Topical, Subcutaneous, Sublingual, Inhalants
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Terminology First pass phenomenon Half-life Minimum effective concentration (MEC) Minimum toxic concentration (MTC) Desired therapeutic range Properties that affect absorption Concentration Properties of the drug molecule Size Ionization
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Class 20 Drug Nutrient Interactions 2011 - Drug-Nutrient...

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