Lecture 20

Lecture 20 - 1 BSCI105 P r i n c i p l e s o f B i o l o g...

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Unformatted text preview: 1 BSCI105 P r i n c i p l e s o f B i o l o g y I FALL 2011 C l i c k e r Q u e s t i o n ! Chemical energy carried by electrons is “harvested” through a series of ________ reactions. 1. Phosphorylation-Dephosphorylation 2. Reduction-Oxidation 3. Catabolic-Anabolic 4. Antagonistic-Cooperative BSCI105 P r i n c i p l e s o f B i o l o g y I FALL 2011 C e l l u l a r R e s p i r a t i o n Harvesting Chemical Energy (Chapter 9) 2 BSCI105 P r i n c i p l e s o f B i o l o g y I FALL 2011 C e l l u l a r R e s p i r a t i o n BSCI105 P r i n c i p l e s o f B i o l o g y I FALL 2011 G l y c o l y s i s 3 BSCI105 P r i n c i p l e s o f B i o l o g y I FALL 2011 T r a n s i t i o n S t e p BSCI105 P r i n c i p l e s o f B i o l o g y I FALL 2011 K r e b ’ s C y c l e s 4 BSCI105 P r i n c i p l e s o f B i o l o g y I FALL 2011 S o f a r … • Started in the cytosol with glucose • Now have from gycolysis • 2 A T P , 2 N A D H from transition step • 2 N A D H from Krebs cycle • 2 A T P , 6 N A D H , 2 F A D H 2 • NADH and FADH 2 have electrons to be harvested! BSCI105 P r i n c i p l e s o f B i o l o g y I FALL 2011 O x i d a t i v e P h o s p h o r y l a t i o n • Uses membrane proteins in mitochondria • Uses oxygen • Uses the transfer of electrons Oxidation-Reduction reactions 5 BSCI105 P r i n c i p l e s o f B i o l o g y I FALL 2011 • In biological systems, the transfer of hydrogen atoms (NOT IONS!) between two molecules is a REDOX reaction Transfer includes the hydrogen atom’s electron • Molecule that gains a hydrogen/electron is “REDUCED” • Molecule that loses a hydrogen/electron is “OXIDIZED” (“LEO”) O x i d a t i o n- r e d u c t i o n r e a c t i o n s “ R e d o x r e a c t i o n s ” BSCI105 P r i n c i p l e s o f B i o l o g y I FALL 2011 C a t a b o l i s m o f g l u c o s e • movement of electrons some molecules are oxidized some molecules are reduced 6 BSCI105 P r i n c i p l e s o f B i o l o g y I FALL 2011 BSCI105 P r i n c i p l e s o f B i o l o g y I FALL 2011 N A D + / N A D H N i c o t i n a m i d e a d e n i n e d i n u c l e o t i d e A “ R e d o x C o u p l e ” 7 BSCI105 P r i n c i p l e s o f B i o l o g y I FALL 2011 NADH + H + + 1/2 O 2 → NAD + + H 2 O Δ G = -52.4 kcals/mol In presence of oxygen, NADH will transfer electrons to oxygen to release energy: N A D + / N A D H BSCI105 P r i n c i p l e s o f B i o l o g y I FALL 2011 E l e c t r o n T r a n s p o r t C h a i n • Series of protein complexes and organic molecules embedded in inner mitochondrial membrane • Coordinates a series of redox reactions • The final electron acceptor is molecular oxygen (O 2 ) 8 BSCI105 P r i n c i p l e s o f B i o l o g y I FALL 2011 E T C • Electrons can enter the ETC from NADH BSCI105 P r i n c i p l e s o f B i o l o g y I FALL 2011 E T C • Electrons can enter the ETC from NADH or from FADH 2 9...
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Lecture 20 - 1 BSCI105 P r i n c i p l e s o f B i o l o g...

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