Midterm I Version 1 Answer Key
Page 1 of 2 
Midterm I Version 1 (Blue)
1. What is the probability that III11 is heterozygous for the GSDII allele?
Answer is e) greater than 80%
III11 is 100% heterozygous
2. What is the probability that their first child will be affected with Glycogen Storage Disease II?
Answer is a) 1/48
Calculation: 1/8 Aa X 2/3Aa X ¼ (aa) = 1/48
3. In individuals homozygous for this allele there would be
Answer is b) normal levels of transcription of the
GSDII
gene which would result in the production
of a poorly functioning alphaglycosidase.
4. The above statements illustrate which of the following phenomena?
Answer is b) i) epigenetic effects, ii) phenocopy effect and iii) allelic heterogeneity
5. What is the approximate probability that their first child will be phenotypically normal?
Answer is e) greater than 60%
6. Which of the following statements best explains the high rate of
alphaglycosidase
gene transcription in
cardiac and skeletal muscle cells?
This preview has intentionally blurred sections. Sign up to view the full version.
View Full Document
This is the end of the preview.
Sign up
to
access the rest of the document.
 Fall '09
 C.SCHISLER
 Genetics, Tay Sachs disease

Click to edit the document details