genetics mock midterm 10

genetics mock midterm 10 - MBG 2000 Introductory Genetics...

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MBG 2000 Introductory Genetics Mock Midterm Exam Fall 2010 It is most beneficial to you to write this mock midterm UNDER EXAM CONDITIONS . This means: Complete the midterm in an hour and 15 minutes. Work on your own. Keep your notes, textbook, and workbook closed. Attempt every question. After the time limit, go back over your work with a different colour or on a separate piece of paper and try to do the questions you are unsure of. Record your ideas in the margins to remind yourself of what you were thinking when you take it up during session. The purpose of this mock midterm is to give you practice answering questions in a timed setting and to help you to gauge which aspects of the course content you know well and which are in need of further development and review. Use this mock midterm as a learning tool in preparing for the actual midterm. Please be advised that we do not have previous knowledge about the content of your midterm, so do not focus your studying simply on the material presented in the mock exam. This version of the mock midterm will be reviewed and discussed during the following SLG sessions: Date and Time Location Leader Wednesday 5:30-8:30pm Library 200B Zoë Thursday 2:30-5:30pm Library 100A (Forster Room) Andrew GOOD LUCK!
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The following Scenario applies to questions 1-4 Gaucher Disease Type I Gaucher Disease Type I (GD-I) is a rare single gene disorder which is fully penetrant. Affected individuals have enlarged livers and spleens, bone abnormalities, and anaemia. GD-I is caused by a defect in the gene that encodes the enzyme glucocerebrosidase. The gene maps to chromosome 1. Glucocerebrosidase functions in the lysosome to degrade certain complex lipids (glucocerebrosides). If the enzyme functions poorly then partially degraded lipids accumulate in the lysosomes of cells. The macrophages of the immune system are particularly sensitive to this process and lipid-laden macrophages accumulate in the bone marrow where they compromise the production of red blood cells and platelets. The pedigree below represents a hypothetical family affected with GD-I. Shaded symbols represent individuals affected with GD-I and open symbols represent phenotypically normal individuals. The following four questions refer to this information. 1. Individual III-2 marries individual III-6. What is the probability that the first child of these parents will be affected with GD-I? a) 1/8 b) 1/12 c) 1/18 d) 1/64 e) none of the above 2. Individual III-8 marries individual III-3. What is the probability that their first child will be a carrier of GD-I? a) ¼ b) 1/6 c) 1/8 d) 1/12 e) none of the above
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Read over the following statements. i) There are a number of inherited diseases that are phenotypically similar to GD-I and each is usually associated with one of the genes that encodes a lysosomal enzyme. For example, Wolman Disease is caused by mutations in a gene found on chromosome 10 and Nieman-Pick Disease is caused by mutations in a gene found on chromosome 11. Both of these diseases are
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genetics mock midterm 10 - MBG 2000 Introductory Genetics...

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