Chapter 4 - Chapter 4 : The Three-Dimensional Structure of...

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Chapter 4 : The Three-Dimensional Structure of Proteins *** A. Overview of Protein Structure a. Five themes a.i. 3D structure determined by AA sequence a.ii. Function depends on structure a.iii. Isolated protein usually exists in one or a small number of stable structural forms a.iv. Most important forces stabilizing the structures maintained by a protein are non-covalent interactions a.v. There are some common structural patterns that help to organize protein architecture b. Conformation —spatial arrangement of atoms in a protein b.i. Possible conformations of a protein is anything that won’t break c-bonds b.ii. Those existing under a given set of conditions are usually those that are thermodynamically more stable (lowest G) c. A Protein’s Conformation Is Stabilized Largely by Weak Interactions c.i. Stability (in terms of protein structure) —tendency to maintain a native conformation c.ii. Unfolded state of a protein characterized by high degree of conformational entropy c.ii.1.
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This note was uploaded on 12/10/2011 for the course BCH 5045 taught by Professor Guy during the Fall '08 term at University of Florida.

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Chapter 4 - Chapter 4 : The Three-Dimensional Structure of...

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