40 - Friday, December 3, 2010 Lecture 40 Announcements: 1....

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
Friday, December 3, 2010 Lecture 40 Announcements: 1. The final exam will be held in STATLER AUD on Monday 12/13 at 2PM . 2. Quiz 10: A 22.8 B 21.7 C 21.3 Bring any quiz 10 for regrading to review sessions or office hrs during Study Week. Pick up any regraded quizzes at the Bio Center. 3. Reminder: Review sessions and office hours during Study Week are as posted on Blackboard. Prof's review session will be Wed 12/8 from 10AM - noon in room 132 of Goldwin Smith Hall. 4 . Note that the VOH will be open until the final exam. Wednesday's lecture: Control of overall metabolism is via hormones. . one category or hormones operates via G-proteins and adenylyl cyclase . another category also operates via G-proteins of a slightly different type, which then activate a phospholipase C that is specific for PIP 2 Today's lecture: At the top left of page 283, you see a different hormone mechanism-- that of steroid hormone action. Overall story: a. Steroid hormones, being predominantly nonpolar, pass through membranes. Once inside the cytosol, they typically enter the nucleus and bind to a receptor protein inside the nucleus. b. Inside the nucleus, the hormone-receptor complex binds to a specific part of DNA, a larger complex assembles, and then the rate of mRNA transcription changes. At the bottom of page 283, note the primary structure (amino acids shown as 1-letter abbreviations) of a steroid receptor. This protein has loops that project from it. These loops are the so-called "Zn-fingers" because of the coordinated zinc atom that stabilizes the projections. . The zinc fingers bind the DNA major groove (see LG p. 39).
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 3

40 - Friday, December 3, 2010 Lecture 40 Announcements: 1....

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online