38 - LECTURE 38 ANNOUNCEMENTS 1. READING AND PROBLEMS AS IN...

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LECTURE 38 ANNOUNCEMENTS 1. READING AND PROBLEMS AS IN LG 2. LAST PyMOL ASSIGNMENT: G-PROTEINS (THE ONLY PyMOL ON FINAL EXAM). MONDAY'S LECTURE: TODAY BIOSYNTHESIS OF NITROGEN-CONTAINING MOLECULES: 3. PLEASE DO EVALUATE THIS COURSE ONLINE. WE GREATLY APPRECIATE YOUR DOING THIS!! LIPID BIOSYNTHESIS: CONTROL OF FATTY ACID SYNTHESIS: ACETYL CoA-CARBOXYLASE MINIMIZING A SUBSTRATE CYCLE OF FA SYNTHESIS AND FA β -OXIDATION SYNTHESIS OF FAT AND PHOSPHOLIPID CHOLESTEROL SYNTHESIS AND TRANSPORT "FIXING" N 2 FROM THE ATMOSPHERE INCORPORATING N INTO OTHER BIOMOLECULES CONTROL OF ALL METABOLISM-- INTRO 4. DO NOT TURN IN QUIZ 10 IF YOU HAVE ALREADY COMPLETED 9 QUIZZES! PATHOLOGY IN ARTERIES CAUSED BY "CHOLESTEROL"
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NORMAL, HEALTHY CELLULAR UPTAKE OF LDL LDL ApoB-100 LDL RECEPTOR RECEPTOR-MEDIATED ENDOCYTOSIS ENDOSOME LYSOSOME CHOLESTEROL ESTER DROPLET FATTY ACIDS AMINO ACIDS LDL RECEPTOR SYNTHESIS NUCLEUS LDL RECEPTOR PROTEIN ON CELL SURFACE BINDS TO APO-B-100 PROTEIN ON LDL SURFACE MOST RECEPTOR PROTEINS RECYCLE TO CELL SURFACE LDL PROTEINS, CHOLESTEROL ESTERS, TAG ALL DEGRADED FOR EVENTUAL USE BY THE CELL. THIS IS NORMAL AND HEALTHY!
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PATHOLOGY: ARTERY BLOCKED; CLOT FORMED FOAM CELLS SEND OUT SIGNALS: MUSCLE CELLS, MACROPHAGES, MIGRATE TO THE AREA LDL STICKS TO, ENTERS, DAMAGED AREA MACROPHAGES TAKE UP LDL CELLS GROW AND REPLICATE THE “LESION” GROWS! SMOOTH SURFACE MACROPHAGE SWOLLEN WITH LDL IS “FOAM CELL” NORMAL CROSS-SECTION NORMAL CROSS-SECTION
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NEW TOPIC: FORMATION, SYNTHESIS OF N -CONTAINING MOLECULES
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G o SOIL : AZOTOBACTERIA, KLEBSIELLA, CLOSTRIDIA FRESH/SALT WATER : CYANOBACTERIA SYMBIOTIC WITH LEGUMES : RHIZOBIA NITROGEN (GAS) FIXING N 2 + 3H 2 2NH 3 VERY HIGH G o TS COMPARE: C - C BOND 350kJ/mol THIS RXN LOOKS “REASONABLE” HOWEVER: THE NITROGENASE COMPLEX ONE TETRAMER ("DINTROGENASE")
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38 - LECTURE 38 ANNOUNCEMENTS 1. READING AND PROBLEMS AS IN...

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