33 - LECTURE 33 ANNOUNCEMENTS 1 Quiz 8 A 19.7 B 20.2 C 20.4 2 TODAY 2:55PM IN COMSTOCK B108 INTERVIEWING FOR HCEC AND MEDICAL SCHOOL EVALUATION

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Unformatted text preview: LECTURE 33 ANNOUNCEMENTS 1. Quiz 8: A 19.7 B 20.2 C 20.4 2. TODAY 2:55PM IN COMSTOCK B108: INTERVIEWING FOR HCEC AND MEDICAL SCHOOL EVALUATION-- WHAT ARE THEY LOOKING FOR? WEDNESDAY’S LECTURE UREA CYCLE OXIDATIVE PHOSPHORYLATION: BRIEF HISTORY AND INTRO TODAY: WHAT HAPPENS AT EACH OF THE 4 COMPLEXES IN THE ELECTRON TRANSPORT CHAIN 3. THE NEXT PyMOL ASSIGNMENT, ATP SYNTHASE (FOR THE QUIZ WED 11/17) 4. HCEC ORIENTATION WED 11/17 (REPEAT OF INFO SESSION OF 11/3) HOWEVER-- BE WARNED: WE WILL NOT REACH ATP SYNTHASE UNTIL THE FIRST HALF OF THE LECTURE ON MONDAY 11/15 "STRATEGY"/OVERVIEW OF ENERGY STORAGE DURING ELECTRON TRANSPORT MITOCHONDRIA AND OXIDATIVE PHOSPHORYLATION HISTORY: KEY QUESTION: MAIN WRONG IDEAS: ROLE OF EF RACKER: ROLE OF PETER MITCHELL: + + NADH + H + 1 / 2 O 2 NAD + H 2 O . ∆ G o ' = -n F ∆ E o ' = -(2)(96.5kJ/ mol V)(1.14V) = -220kJ/ mol MAG 11,000x MAG 37,000x MAG 4,000,000x PRE- 1940: UREA CYCLE, CAC DURING 1940s: ROLES OF ATP, NADH, FADH2 HOW NADH & FADH 2 ATP KENNEDY & LEHNINGER: RXNS OF ATP SYN. OCCUR IN MITOCHONDRIA! BIG DISCOVERY: MADE SIMPLIFIED MITO. PREPARATION: ATP FORMS FROM NADH or FADH 2 ONLY IF MITO. MEMBRANES INTACT ! GLYCOLYSIS NOBEL PRIZE: MEMBRANES STORE THE ENERGY ! ENERGY IS STORED AS ∆ G TRANSPORT OF GRADIENT OF H + and ∆ Ψ ACROSS INNER MITO. THIS CONCEPT IS CALLED “CHEMIOSMOTIC THEORY” WE CAN ESTIMATE HOW MUCH ∆ G COULD BE STORED IF ALL ENERGY FROM NADH OX. USED TO CREATE GRADIENT OF H + and ∆ Ψ 1 “SUBSTRATE-LEVEL”i.e. HIGH-ENERGY INTERMEDIATE FORMS FROM SUBSTRATES NADH, FADH 2 (LIKE 1,3-BPG, PEP, SUCC-CoA) 2 NADH or FADH 2 CREATE “HIGH-ENERGY STATE OF ENZ”, WHICH THEN FORMS ATP WOW!...
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This note was uploaded on 12/10/2011 for the course BCHEM 3350 taught by Professor Feig during the Fall '09 term at Cornell University (Engineering School).

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33 - LECTURE 33 ANNOUNCEMENTS 1 Quiz 8 A 19.7 B 20.2 C 20.4 2 TODAY 2:55PM IN COMSTOCK B108 INTERVIEWING FOR HCEC AND MEDICAL SCHOOL EVALUATION

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