31 - LECTURE 31 ANNOUNCEMENTS 1. PROBLEM ASSIGNMENTS AS IN...

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LECTURE 31 ANNOUNCEMENTS 1. PROBLEM ASSIGNMENTS AS IN LG; AND PyMOL #9, ATP SYNTHASE FRIDAY'S LECTURE COMPLETE OX OF ACETYL GROUP ( COMPLETING THE OX OF GLUCOSE) CONTROL AT THE 3 STEPS WHERE ENZYMES NOT FULLY ACTIVE-- RECOGNIZE BY LARGE NEGATIVE G OF THE RXN. PDH COMPLEX RXN RATE ALSO UNDER CONTROL. CAC INTERMEDIATES ARE DIRECTLY CONNECTED TO AA BIOSYN, FATTY ACID AND RXNS OF THE CITRIC ACID CYCLE : FATTY ACID UPTAKE FROM DIET: NO CONTROL! TODAY FATTY ACID CATABOLISM BY β -OXIDATION; "KETONE BODIES" AMINO ACID CATABOLISM 2. CHECK YOUR EXAM WEEK SCHEDULE. IF YOU HAVE A CONFLICT, MEET BRIEFLY AFTER CLASS WED 11/10 FA RELEASE FROM STORED FAT: HORMONAL CONTROL
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LONG-CHAIN FATTY ACID FATTY ACYL ADENYLATE (ENZYME-BOUND) 1 2 PRODUCT: FATTY ACYL-CoA ALL ENZYMES FOR FA OX. ARE IN MITOCHON. MATRIX IN OUTER MITO. MEMBRANE, THIS RXN: 2-STEP RXN IN ACTIVE SITE of FATTY ACYL-CoA SYNTHETASE HOW FA IN CYTOSOL GETS INTO THE MITOCHONDRIAL MATRIX ATP & FA BIND IN ACTIVE SITE, THEN NUCLEOPHILIC ATTACK FORMS FATTY ACYL ADENYLATE CoA BINDS IN ACTIVE SITE, THEN NUCLEOPHILIC ATTACK FORMS FATTY ACYL-CoA TO DRIVE RXNS AND , A G EFFECT: PRODUCT [PP i ] MADE LOW BY ITS HYDROLYSIS via A DIFFERENT ENZYME FA CONVERTED TO "ACTIVATED" FORM (JARGON: ACTIVATED = "HIGH ENERGY" = UNSTABLE);
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31 - LECTURE 31 ANNOUNCEMENTS 1. PROBLEM ASSIGNMENTS AS IN...

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