28 - ANNOUNCEMENTS LECTURE 28 1. QUIZ 7 THIS WEDNESDAY 11/3...

Info iconThis preview shows pages 1–4. Sign up to view the full content.

View Full Document Right Arrow Icon
LECTURE 28 1. QUIZ 7 THIS WEDNESDAY 11/3 (NO PyMOL). QUIZ 8 WILL BE WEDNESDAY, 11/10. QUIZ 9 WILL BE ON 11/17. THE LAST QUIZ, #10, WILL BE ON 12/1. 3. THIS WEEK'S ASSIGNMENTS AS IN LG, WITH THE ADDITION OF Ch15 #4. ANNOUNCEMENTS 2. MAKING HOLIDAY PLANS? NO LECTURE ON WED 11/24 . FRIDAY’S LECTURE MECHANISM OF GAPDH CONTROL OF GLYCOLYSIS AT THE STEPS OF LARGE NEGATIVE G GLYCOGEN PHOSPHORYLASE TODAY: CONTROL OF GP, HK, PFK-1, AND PK PATTERNS OF CONTROL: HORMONAL CONTROL AND "LOCAL" CONTROL ALSO PyMOL: #8, PHOSPHOFRUCTOKINASE (NO PyMOL REVIEW TOMORROW) 4. WHEN STUDYING A METABOLIC PATHWAY…. NO GETTING AROUND IT! YOU MUST STUDY EACH STEP CAREFULLY ON YOUR OWN AT WHAT LEVEL OF DETAIL?! SEE LAST YEAR'S QUIZZES #7 & 8 5. RE-GRADING: ATTACH WRITTEN ARGUMENT TO EXAM, PLACE IN PURPLE FOLDER
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
CONTROL: ROLE OF GLYCOGEN PHOSPHORYLASE = GP THIS IS A REGULATED RXN PRIOR TO START OF ACTUAL GLYCOLYSIS! THE BASIC IDEA: 1. GLUCOSE (GLC) IS IMPORTANT! WHEN NEEDED, NO TIME TO SYNTHESIZE IT. 2. GLC STORED AS POLYMER (GLYCOGEN), CLEAVED OFF AS NEEDED HPO 4 = ADDS ACROSS GLYCOSIDIC BOND RXN CATALYZED BY GP: PRODUCT OF GP-CATALYZED RXN IS GLUCOSE-1-P H 1 micron ELECTRON MICROGRAPH OF LIVER CELL AFTER A MEAL. CLUSTERS OF GLYCOGEN GRANULES ARE DARK GP IS BOUND TO GLYCOGEN GRANULES CONTROL GP
Background image of page 2
GLYCOGEN PHOSPHORYLASE: HORMONAL CONTROL OF GP ! “METABOLIC LOGIC” A. RESTING MUSCLE HAS SUFFICIENT GLC GLYCOGEN SHOULD NOT BE CLEAVED TO G-1-P B. ENTIRE ANIMAL NEEDS GLC. USE SIGNAL THAT TRAVELS THRU BLOOD TO REACH ALL PARTS: HORMONE AMPLIFICATION C. HOWEVER, EACH CELL HAS ITS OWN [GLC], [ATP], [AMP], [G-6-P]. THESE ARE LOCAL SIGNALS
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 4
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 11

28 - ANNOUNCEMENTS LECTURE 28 1. QUIZ 7 THIS WEDNESDAY 11/3...

This preview shows document pages 1 - 4. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online