19 - LECTURE 19 ANNOUNCEMENTS 1 QUIZ 5 RESULTS A 20.6 B...

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LECTURE 19 ANNOUNCEMENTS 1. QUIZ 5 RESULTS: A 20.6 B 20.6 C 19.0 3. PyMOL ASSIGNMENT #6, CHYMOTRYPSIN 2. MIDTERM EXAM: THURS 10/21, 7:30 - 10PM; (ROOM TBA) MAKE-UP: SUN 10/24, NOON – 2:30 (e-MAIL PROF BY TODAY WITH CONFLICT). ROOM TBA. WEDNESDAY’S LECTURE TODAY 4. HOW TO STUDY FOR THE MIDTERM?! DISCUSS FRI 10/15 2:55PM COMSTOCK B108 LAST YEAR'S EXAM IS ON OUR WEB SITE; BE ABLE TO ANSWER ALL QUIZ, HOMEWORK QUESTIONS; UNDERSTAND EVERY WORD FROM LECTURES; USE THE TEXT AS A SUPPLEMENT WHY SO MANY NON-AA COMPONENTS OF PROTEINS? 5. REMINDER: NO QUIZ WED 10/13 or 10/20 CONTROL OF ENZYME DEGRADATION PyMOL REVIEWS SUN 10/17 (CARPENTER); TU 10/19 (251 MALOTT). USUAL TIMES CONTROL OF ENZYME ACTIVITY 1. ALLOSTERIC; 2. COVALENT MODIFICATION CONTROL OF ENZYMES: REGULATION OF SYNTHESIS OF THE PROTEIN
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B. CONTROL OF PROTEIN DEGRADATION ATP + UBIQUITIN PEPTIDE FRAGMENTS ELECTRON MICROSCOPY IMAGE OF PROTEASOMES ENZYME REGULATION b . "HEALTHY" PROTEIN CAN ALSO BE HYDROLYZED! i. FASTING: SYN ~ SAME, BUT HYDROLYSIS ; ii. INFECTION: MUSCLE PROTEIN HYDROL; iii. CELL DEATH (APOPTOSIS): SIGNAL IS RECEIVED, A SERIES OF PROTEASES ACTIVATED iv. DURING CELL CYCLE, PROTEINS APPEAR, ACT FOR ~ MINUTE, THEN DEGRADED 76 AA PROTEIN, FOUND IN ALL CELLS AS MARKER FOR PROTEOLYSIS THE PROTEASOME. 4 ROWS OF 7 SUBUNITS TOTAL MW ~2000kD “PROTEIN MACHINE” 1 PROTEIN LIFETIMES: HISTONES ~ LIFE OF CELL; Hb MONTHS; MITOTIC CYCLIN ~ 2 MIN 2 PRINCIPLES: a . PROTEIN THAT PARTIALLY UNFOLDS OR CHEM REACTS (e.g. OX.) IS RECOGNIZED AND THEN HYDROLYZED; 3 MECHANISMS: i. IN LYSOSOME , PROTEINS AND WHOLE ORGANELLES DEGRADED BY VARIOUS PROTEASES; ii. IN CYTOSOL , SEVERAL PROTEOLYTIC MECHANISMS. OCTOBER 6, 2004:
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19 - LECTURE 19 ANNOUNCEMENTS 1 QUIZ 5 RESULTS A 20.6 B...

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