18 - Wednesday October 6 2010 Lecture 18 Announcements Have...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
Wednesday, October 6, 2010 Lecture 18 Announcements: Have a prelim conflict for Thursday 10/21? Meet briefly after class today to determine the date/time for the make-up prelim. (This meeting has now occurred. The make-up exam will be Sunday 10/24 from noon - 2:30PM. Room to be announced. Send Prof. F. an e-mail! You MUST send an e-mail, describe your conflict, then you get onto “the list”) Monday's lecture: conventions for illustration of mechanism of an enzyme-catalyzed rxn step-by-step mechanism of chymotrypsin Today's lecture: Page 137. Now let's consider another topic of enzyme chemistry: why do proteins have non-amino acid components? Here are some reasons: 1. Amino acid chemistry is limited! For example, side chains cannot have a positive charge any more concentrated than the NH 3 + positive charge. 2. Amino acids have little ability to take part in reversible oxidation/reduction reactions, except the breaking of disulfide bonds. But enzyme -S-S- transition to SH & SH is not used often in catalysis since enzyme structure can change when disulfide bonds are broken! . For these and many more reactions, enzymes incorporate specialized small molecules and ions. As this course progresses, you will notice many non-amino acid constituents at the enzyme active sites. p. 138
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 3

18 - Wednesday October 6 2010 Lecture 18 Announcements Have...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online