17 - LECTURE 17 ANNOUNCEMENTS 1. ASSIGNMENTS FOR THIS WEEK...

Info iconThis preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon
LECTURE 17 ANNOUNCEMENTS 1. ASSIGNMENTS FOR THIS WEEK AS IN LECTURE GUIDE PLUS: READING IN TEXT 220- 2. PyMOL # 6, CHYMOTRYPSIN: THE ONE AND ONLY PyMOL ASSIGNMENT TO APPEAR ON THE MIDTERM EXAM. ** NO OFFICE HRS OR REVIEWS FOR THIS PyMOL UNTIL SUN 10/17! 3. CONFLICT FOR MIDTERM EXAM Th 10/21 7:30PM? E-MAIL PROF BEFORE FALL BREAK TO DESCRIBE CONFLICT . MEET BRIEFLY AFTER CLASS ON WED 10/6 TO SET THE DAY AND TIME . PERHAPS SAT 10/23 OR SUN 10/24? FRIDAY’S LECTURE TODAY HOW TO COMPARE "EFFICIENCY" OF DIFFERENT ENZYMES IRREVERSIBLE INHIBITION USE OF pH TO LEARN ABOUT IONIZABLE RESIDUES AT THE ACTIVE SITE COMPETITIVE AND NON-COMPETITIVE INHIBITION CHYMOTRYPSIN MECHANISM, STEP-BY-STEP CONCEPT OF “TURNOVER NUMBER” AND TIME REQUIRED FOR ALL CHEMICAL STEPS
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
MANY ENZYMES THAT CATALYZE HYDROLYSIS OF PEPTIDE BONDS USE SAME CATALYTIC MECHANISM: TRYPSIN, CHYMOTRYPSIN, ELASTASE, THROMBIN (PART OF BLOOD-CLOTTING MECHANISM), PLASMIN (PART OF CLOT- DISSOLVING MECHANISM) BOTH HIS 57 AND SER 195 HAVE DIRECT CATALYTIC ROLES. THE “TRIAD” KEEPS ALL 3 PRECISELY ALIGNED ELASTASE THROMBIN STRUCTURE: ALL PROTEINS IN THIS FAMILY HAVE SER-HIS-ASP , CALLED THE “CATALYTIC TRIAD” LOWERS G o OF EVERY STEP OF CATALYSIS THAT INVOLVES H + TRANSFER; AND IT BINDS THE TS. CHYMOTRYPSIN
Background image of page 2
Image of page 3
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 15

17 - LECTURE 17 ANNOUNCEMENTS 1. ASSIGNMENTS FOR THIS WEEK...

This preview shows document pages 1 - 3. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online