14 - LECTURE 14 ANNOUNCEMENTS: READING & PROBLEMS...

Info iconThis preview shows pages 1–4. Sign up to view the full content.

View Full Document Right Arrow Icon
LECTURE 14 FRIDAY’S LECTURE: ALL CHEMICAL REACTIONS IN LIFE ARE CATALYZED REACTIONS. NO EXCEPTIONS. HOW DO THESE CATALYSTS WORK? ENZYME COMMISSION NOMENCLATURE ENZYME SPECIFICITY ANNOUNCEMENTS: TODAY: PyMOL: ASSIGNMENT #5, THE PROTEIN DATA BANK INTRO TO RXN RATES GIBBS FUNCTION TRANSITION STATE WHY RXNS TAKE TIME TO OCCUR?! HOW CATALYSTS WORK HOW TO STUDY ENZYMES AS CATALYSTS AS FOR MAKE-UP MIDTERM AND FINAL EXAMS: SEE BLACKBOARD FOR OUR POLICY
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
WHAT CATALYSTS DO CATALYSTS LOWER TRANSITION STATE FREE ENERGY. THERE ARE ONLY TWO WAYS TO DO THIS: 1. DIRECTLY BIND THE TS 2. CHANGE THE RXN PATHWAY: 1 BINDING THE TS ENZYMES ALWAYS DO THIS SIMPLE EXAMPLE FROM ORGANIC CHEM. ETHYLENE HYDROGEN ETHANE SIMPLE CASE OF “DIRECTLY BINDING THE TS”: REACTANTS HELD AT ~ SAME HEIGHT ABOVE Ni CRYSTAL SURFACE BY WEAK BONDING THE PARTICULAR ORIENTATION NECESSARY FOR RXN IS NOW MORE LIKELY! (ENTROPY OF TS REDUCED LESS UNLIKELY) UNCATALYZED TS CATALYZED TS , WITH REACTANTS AT SAME LEVEL ABOVE Ni SURFACE ENZYMES ALSO HOLD THEIR SUBSTRATES IN PRECISE ORIENTATION FOR RXN-- BUT THEY DO THIS IN 3 DIMENSIONS AND STABILIZE IT; NEW TS HAVING LOWER G o
Background image of page 2
2 CHANGING THE RXN PATHWAY
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 4
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 10

14 - LECTURE 14 ANNOUNCEMENTS: READING & PROBLEMS...

This preview shows document pages 1 - 4. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online