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13 - LECTURE 13 ANNOUNCEMENTS QUIZ 3 A 25.2 B 27.2 C 25.4...

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LECTURE 13 WEDNESDAY’S LECTURE: ANNOUNCEMENTS: QUIZ 3: A 25.2 B 27.2 C 25.4 PROF. FEIGENSON WILL MEET WITH ANY 3310 STUDENTS, TODAY, 9/24 FROM 2:55 - 4PM IN COMSTOCK B108: “APPLYING TO GRADUATE SCHOOL-- WHAT ARE THEY LOOKING FOR?" TODAY: ENZYMES! AN INTRO BOTH THE BOHR EFFECT AND HOW FETAL Hb GETS O 2 FROM THE MOTHER ARE EXPLAINED BY ION PAIRS AND THE T R TRANSITION INTRO TO KINETICS 2-STATE MODEL VS SEQUENTIAL MODEL FOR Hb BINDING O 2 THE T R TRANSITION IN Hb EVOLVED AFTER Mb TO CREATE A CONTROLLED OXYGEN TRANSPORT MOLECULE
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ENZYMES! SUBSTRATE: ALIPHATIC, AROMATIC-OH C-OH IS e - DONOR REDOX RXN IS CATALYZED NAD + or NADP + IS e - ACCEPTOR 7. Membrane transporters Na + K + ATPase 3.6.3 MEMBRANE TRANSPORTERS Na + K + ATPase 3.6 HYDROLYZE ACID ANHYDRIDES 3.6.4 HYDROLYZE ATP 3.6.5 HYDROLYZE GTP ON THIS PAGE: OFFICIAL 6 CATEGORIES FROM ENZYME COMMISSION, EC 2.7 TRANSFER PO4 2.7.1 ACCEPTOR -OH 2.7.1.2 SUBSTRATE GLUCOSE *7*. Transporters Na + K + ATPase
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THE EC NOMENCLATURE IS SYSTEMATIC. REAL BIOCHEMISTS ARE JARGON-HAPPY: EC 3.6.4.10 IS ALWAYS CALLED “hsp 70” EC 2.7.7.7 IS DNA POLYMERASE I, CALLED “POL I” VERY CONCISE ADDITIONAL INFO AT WIKI "EC NUMBER" OR GOOGLE “ENZYME COMMISSION” FOR MORE INFO
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ABSOLUTE SPECIFICITY THE RANGE OF ENZYME SPECIFICITY e.g. NH 2 -C-NH 2 + 2H 2 O + H + 2NH 4 + + HCO 3 - O = UREASE ABSOLUTE FUNCTIONAL GROUP SPECIFICITY ALCOHOL DEHYDROGENASE O e.g. CH 3 -CH 2 -OH + NAD + CH 3 -CH + NADH + H + = -CH 2 -OH + NAD + -CH + NADH + H + = O ALCOHOL DEHYDROGENASE RELATIVE FUNCTIONAL GROUP SPECIFICITY e.g. PEPTIDE 1 -C-N-CH-C-N- PEPTIDE 2 + H 2 O = = O O H H ARG PEPTIDE 1 -C-N-CH-C- = = O O H O - ARG + + NH 3 - PEPTIDE 2 TRYPSIN ARG = But also: -C-N-CH-C-O-CH 3 + H 2 O = O O H = But also: -C-N-CH-C-O = O O H ARG TRYPSIN - + CH 3 -OH
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