12 - PUT AWAY ALL NOTES BOOKS NOW NO CELL PHONES WITHIN...

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PUT AWAY ALL NOTES, BOOKS NOW NO CELL PHONES WITHIN REACH NO TALKING DURING THE QUIZ NO GRAPHING CALCULATORS
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LECTURE 12 ANNOUNCEMENTS 1. YOUR NEXT PyMOL EXERCISE: #4 HEMOGLOBIN. PRINT OUT THE INSTRUCTIONS. MONDAY’S LECTURE: COMPARISON OF STRUCTURE OF Mb WITH Hb α AND β CHAINS INTRODUCTION TO THE SIGMOID CURVE AND ION PAIRS IN DEOXY Hb TODAY: DETAILS REALLY DO MATTER! HEMOGLOBIN ACTION EXPLAINED BY ION PAIRS. COMPLETELY. ALMOST COMPLETELY. 2. PROF. FEIGENSON WILL MEET WITH ANY 3310 STUDENTS, THIS FRIDAY, 9/24 FROM 2:55 - 4PM IN COMSTOCK B108: “APPLYING TO GRADUATE SCHOOL-- WHAT ARE THEY LOOKING FOR?" 3. INTERESTED IN VOLUNTEER MEDICAL WORK OVER WINTER BREAK? HOW ABOUT ONE WEEK IN A RURAL PART OF EQUADOR OR PERU?
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WHY WOULD O 2 BINDING DISRUPT DISTANT ION PAIRS ?! i.e. HOW IS HEME CONNECTED TO SUBUNIT CONTACTS OF IV? EXPLANATION PROPOSED BY MAX PERUTZ, NOBEL PRIZE- WINNER WHO GREATLY INFLUENCED UNDERSTANDING OF Hb: PROXIMAL HIS IS BOUND TO Fe 2+ , MOVES WHEN O 2 BINDS, DRAGGING HELIX F, BREAKING SUBUNIT ION PAIRS
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