11 - ANNOUNCEMENTS: LECTURE 11 READING & PROBLEMS AS IN...

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LECTURE 11 ANNOUNCEMENTS : READING & PROBLEMS AS IN LG FOR THIS WEEK; PyMOL #4, HEMOGLOBIN ALL INFO ABOUT PROTEIN FOLDING IS IN THE AA SEQUENCE. BUT CORRECT DISULFIDES, AND CORRECT cis vs trans NEXT TO PROLINE ARE SLOW WITHOUT ENZYMES. PROTEINS CAN FOLD IN A SHORT TIME, TYPICALLY SEC - MIN: NOT UNDERSTOOD! TODAY: DETAILS OF FOLDING PROCESS? SEC STRUCTURE FORMS FIRST, OR "HYDROPHOBIC COLLAPSE" FIRST? THE "MOLTEN GLOBULE" STATE FORMS BEFORE NATIVE FOLD FRIDAY'S LECTURE: ** SOME DISEASES ARE CAUSED BY PROTEIN MISFOLDING: "AMYLOID DEPOSITS" AR AGGREGATES OF MISFOLDED PROTEIN. HUNTINGTON'S DISEASE, ALZEIMER'S, THE PRION DISEASES: PROTEINS ALL β PROTEIN FUNCTION COMES FROM PROTEIN STRUCTURE: START OF THE HEMOGLOBIN STORY QUIZZES THAT HAVE BEEN REGRADED AND RECORDED ARE IN THE GREEN FOLDER; EACH FRIDAY, THESE WILL BE BROUGHT OVER TO THE BIOLOGY CENTER MOVEMENTS WITHIN ALL PROTEINS MISFOLDING; ROLES OF MOLECULAR CHAPERONES
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2 CARRIERS ROLE OF HEME Mb SHAPED TO FIT HEME, HOLD IN CREVICE O 2 PRESSURE, mm Hg 0 25 50 75 100 θ = FRACTION OF HEMES SATURATED WITH O 2 0 1.0 0.5 Hb Mb IN O 2 -STARVED TISSUE WANT IT SATURATED WITH O WANT IT SATURATED WITH O 2 IN LUNGS, BUT GIVING UP O IN LUNGS, BUT GIVING UP O 2 IN TISSUE HEY! NOTICE THE SHAPE OF THIS CURVE: "SIGMOID" WHAT WOULD BE THE IDEAL PROPERTIES OF A MOLECULE DESIGNED TO PICK UP O 2 IN LUNGS, DELIVER O 2 TO THE TISSUE?
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This note was uploaded on 12/10/2011 for the course BCHEM 3350 taught by Professor Feig during the Fall '09 term at Cornell University (Engineering School).

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11 - ANNOUNCEMENTS: LECTURE 11 READING & PROBLEMS AS IN...

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