9 - LECTURE 9 1. MEET WITH INTERESTED STUDENTS, FRIDAY...

Info iconThis preview shows pages 1–5. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: LECTURE 9 1. MEET WITH INTERESTED STUDENTS, FRIDAY 9/17, 2:55 - 4 PM, COMSTOCK B108: TRANSFER STUDENTS-- HOW TO SUCCEED AT THIS PLACE MONDAYS LECTURE: ANNOUNCEMENTS: MANY PROTEINS HAVE MORE THAN ONE, SOMETIMES MANY, FOLDS IN ONE CHAIN ASSOCIATION OF MORE THAN ONE POLYPEPTIDE CHAIN = QUATERNARY STRUCTURE, IV CAN BE STABLE IV , e.g. HEMOGLOBIN CAN BE A TRANSIENT IV COMPLEX, e.g. INSULIN SIGNALING COMPLEX TODAY: PROTEIN IS STABLE, BUT NOT VERY! AND HOW DOES IT FOLD UP?!?! THERMODYNAMIC VIEW OF PROTEIN FOLDING: NATIVE STRUCTURE HAS LOWEST G 2. ITHACA HEALTH EDUCATION PROGRAM INFO MEETING THURSDAY 9/16 3. RE-GRADED QUIZZES--HOW TO GET THEM BACK? CHECK GREEN FOLDER ON FRONT DESK. BUT AFTER ~ ONE WEEK, THESE ALSO GO TO THE BIO CENTER RESERVE DESK. FOLD O H H O H H O H H O H H O H H O H H O H H O H H O H H O H H O H H O H H O H H O H H O H H O H H O H H O H H O H H O H H O H H O H O H H O H O H H O H H O H H O H H O H H O H H O H H O H H O H H O H H O H H O H H UNFOLD FOLDED OR UNFOLDED, ~ALL H-BONDS ARE MADE SIMILARLY, FOLDED OR UNFOLDED: IONIC ATTRACTIONS, WEAK INTERACTIONS ONLY SLIGHTLY FAVORABLE FOLDED H-BONDS WITHIN PROTEIN H-BONDS TO WATER HOW TO DESCRIBE PROTEIN STABILITY WITH A GRAPH? SIMPLE EXAMPLE: POLY(GLU); SIDECHAIN CAN BE CH 2-CH 2-COOH OR CH 2-CH 2-COO- NOTE: STRUCTURAL COORDINATES SCALE IS ARBITRARY ! HERE WE LET x REPRESENT -HELIX ON STRUCT. COORD AXIS MEANING...
View Full Document

Page1 / 9

9 - LECTURE 9 1. MEET WITH INTERESTED STUDENTS, FRIDAY...

This preview shows document pages 1 - 5. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online