8 - LECTURE 8 ANNOUNCEMENTS 1 THIS WEEK LG PROBLEMS 10 17...

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Unformatted text preview: LECTURE 8 ANNOUNCEMENTS 1. THIS WEEK: LG PROBLEMS 10 - 17; PyMOL ASSIGNMENT #3, PROTEIN FOLDS. 3. ANY STUDENT WHO HAS JUST ADDED THIS CLASS: MEET PROF RIGHT AFTER LECTURE TO DISCUSS HOW TO CATCH UP. FRIDAY’S LECTURE: β-SHEETS, TURNS, COLLAGEN STRUCTURE FOLDS, SUPERFAMILIES, FAMILIES: ONLY ABOUT 1000 DIFFERENT KINDS OF "FOLDS" TODAY'S LECTURE: SUPERFAMILY OF EUKARYOTIC PROTEIN KINASES MULTI-FOLD PROTEINS QUATERNARY STRUCTURE (IV) PROTEIN STABILITY 2. RE-GRADING POLICY: PUT QUIZ, WITH WRITTEN EXPLANATION/REQUEST FIRMLY ATTACHED , IN THE PURPLE RE-GRADE FOLDER ON THE TABLE AT THE FRONT OF THE LECTURE ROOM. NO ORAL ARGUMENTS-- ONLY WRITTEN REQUESTS ATTACHED TO QUIZ . 4. INTERESTED IN THE CU UNDERGRAD HEALTH COOPERATIVE? SOME FAMILIES WITHIN THE SUPERFAMILY: THE HUMAN "KINOME" ≡ THE KINASE SUPERFAMILY ALL CATALYZE PO 4 CHEM. MOD. OF TYR, THR, OR SER = TK ≡ TYROSINE IS TARGET TKL ≡ TYROSINE KINASE-LIKE AGC ≡ INCLUDES PROTEIN KINASE A, PROTEIN KINASE G, AND PROTEIN KINASE C CONTAINS 8 FAMILIES; THE PROTEINS WITHIN EACH FAMILY ARE CLOSELY RELATED TO EACH OTHER BY AA SEQUENCE AND ENZYME BEHAVIOR THE KINASE SUPERFAMILY PROTEINS IN THIS SUPERFAMILY HAVE SAME FOLD: "PROTEIN KINASE-LIKE" ; ALL 518 PROTEINS HAVE STRUCTURAL & EVOLUTIONARY RELATIONSHIP PYRUVATE KINASE ALL LARGE PROTEINS: MORE THAN ONE FOLD BUT: A FOLD CAN FORM FROM NON-CONTINUOUS AA SEQUENCES PROTEINS HAVING MULTIPLE FOLDS WITHIN A SINGLE POLYPEPTIDE CHAIN AA 116-223 AA 1-115 AND 224-387 AA 388-530 CONSIDERING ALL LIFE FORMS : ALL THE TYPES OF INDIVIDUAL PROTEIN FOLDS ARE FOUND IN ALL LIFE FORMS! PROTEIN STRUCTURES DIFFER IN THE WAYS THAT FOLDS ARE COMBINED. 66kD CHAIN OF HIV REVERSE TRANSCRIPTASE A FOLD OFTEN IS A CONTINUOUS SEQUENCE OF AA NH 3 + COO _ REPEATED FOLDS CAN OCCUR (WITHIN A SINGLE POLYPEPTIDE CHAIN) COMPLEMENT CONTROL PROTEIN FOLD (C) IMMUNOGLOBULIN FOLD (I) FIBRONECTIN TYPE I FOLD (F1) GROWTH FACTOR FOLD (G) MANY PROTEINS: POLYPEPTIDE CHAIN HAS REPEATING RUNS OF SAME FOLD KRINGLE FOLD (K) 4 AQUEOUS PROTEINS OR 3 PROTEINS IN THE MEMBRANE BIOMEMBRANE FIBRONECTIN BLOOD CLOTTING FACTOR XII BLOOD CLOTTING FACTORS VII, IX, & X...
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8 - LECTURE 8 ANNOUNCEMENTS 1 THIS WEEK LG PROBLEMS 10 17...

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