4 - ANNOUNCEMENTS LECTURE 4 1 RE QUIZ 1 PROF WILL CUT THIS...

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LECTURE 4 1. RE QUIZ 1: PROF WILL CUT THIS FRIDAY'S LECTURE ABOUT 5 MIN SHORT, AND TELL YOU WHAT WILL BE ON THE WED 9/8 QUIZ. ANNOUNCEMENTS: 2. USE THE VOH! SEND MAIL TO [email protected] 3. ANY INTERESTED STUDENTS: “DID YOU FIND A LAB RESEARCH POSITION? WHAT IS EXPECTED OF A NEWBIE RESEARCHER?!", 2:55 - 4:10PM, FRIDAY IN COMSTOCK B108. WEDNESDAY’S LECTURE: IONIZABLE GROUPS THE HYDROPHOBIC EFFECT TODAY: 1. WHAT CAN WE SAY ABOUT PROTEINS WITHOUT KNOWING THE 3D STRUCTURE? PEPTIDES PROTEIN STRUCTURE 2. FINDING THE 3D STRUCTURE INTRO TO MYOGLOBIN ISOZYMES; GUESS PROTEIN FUNCTION; SPECIAL AA SEQUENCES; COMPUTE? X 6. CHECK OUT AXE, THE PROFESSIONAL CHEMISTRY FRATERNITY! 5. WANT TO FIND OUT ABOUT THE RESEARCH PAPER? 4. PyMOL REVIEWS: SUNDAY IN CARPENTER HALL COMPUTER LAB RED ROOM; TUESDAY IN 251 MALOTT: GETTING INTO MALOTT AFTER 4:30PM 7. NO NEED TO E-MAIL PROF RE EXAM CONFLICTS HAVING PyMOL TROUBLES?! SEE BLACKBOARD
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MYOGLOBIN BEHAVIOR PROPERTIES: SHOW O BINDING TWO WAYS: 2 153 AA, MW 17,000 IN MUSCLE CELLS; STORES O 2 [O 2 ] IN WATER ~ 0.3mM [MbO 2 ] IN CELLS ~ 100mM 1 AS AN EQUATION: Mb + O 2 MbO 2 DEOXY FORM OXY FORM 2 AS A GRAPH 1.0 0.5 - - UNITS OF PRESSURE: 1 TORR = 1mmHg = 0.133 kPa TEXT USES kPa = kilo Pascal Hb Mb Mb RED BLOOD CELL
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2 BIND TO Mb? JARGON : NON-AA STRUCTURE COVALENTLY BOUND IN PROTEIN PROSTHETIC GROUP HOLOPROTEIN ENTIRE PROTEIN PLUS PROSTHETIC GROUP APOPROTEIN PROTEIN WITHOUT ITS PROSTHETIC GROUP e.g. "APOMYOGLOBIN" Fe 2+ IS USUALLY 6-COORDINATED 4 POSITIONS OCCUPIED BY HEME N 6 THEN: WHY NOT HAVE ONLY HEME FOR BINDING O 2 ?! HEME
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This note was uploaded on 12/10/2011 for the course BCHEM 3350 taught by Professor Feig during the Fall '09 term at Cornell.

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4 - ANNOUNCEMENTS LECTURE 4 1 RE QUIZ 1 PROF WILL CUT THIS...

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