40 - LECTURE 40 THE VERY LAST ONE! ANNOUNCEMENTS 1. QUIZ 10...

Info iconThis preview shows pages 1–4. Sign up to view the full content.

View Full Document Right Arrow Icon
LECTURE 40 THE VERY LAST ONE! ANNOUNCEMENTS 1. QUIZ 10 A 22.8 B 21.7 C 21.3 WEDNESDAY’S LECTURE MANY HORMONES WORK VIA G-PROTEINS ROLE OF cAMP AND OTHER "SECOND MESSENGERS" Ca ++ , IP 3 , and DAG TODAY HOW STEROID HORMONES WORK HOW INSULIN WORKS 2. FINAL EXAM: i. COMPREHENSIVE, BUT ~ 2/3 ON MATERIAL AFTER MIDTERM; ii. DO NOT MEMORIZE OVERALL RXN EQUATION FOR ANY METABOLISM iii. MUCH MORE INFO IN PROF’S REVIEW WED 12/8 3. PLEASE DO NOT E-MAIL PROF TO ASK WHAT WILL BE ON THE FINAL EXAM FOR REGRADING, BRING QUIZ 10 TO A REVIEW SESSION OR OFFICE HOURS DURING STUDY WEEK
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
HORMONE ACTION: 3 CATEGORIES PEPTIDE OR AMINE HORMONE BINDS TO RECEPTOR ON OUTSIDE OF CELL; ACTS VIA RECEPTOR, NOT BY ENTERING CELL. (1) CYTOSOLIC ENZYMES AFFECTED; (2) TRANSCRIPTION OF mRNA IN NUCLEUS AFFECTED (3) STEROID OR THYROID HORMONE ENTERS CELL; HORMONE- RECEPTOR COMPLEX ACTS ON TRANSCRIPTION IN NUCLEUS INSULIN WORKS BY BOTH 1 AND 2 ESTRADIOL WORKS BY 3 NOTE THE ASSEMBLY OF A TRANSIENT IV COMPLEX ON DNA
Background image of page 2
TAMOXIFEN STEROID HORMONE ACTION PASS THRU MEMBRANES; BIND RECEPTOR PROTEIN IN NUCLEUS (OR CYTOSOL) CHANGE RATE OF mRNA TRANSCRIPTION HRE = HORMONE RESPONSE ELEMENT A REGION OF DNA. WHAT BINDS HRE ? AFTER HORMONE BINDS RECEPTOR, THE RECEPTOR CHANGES STRUCTURE: IT DIMERIZES ! THEN, MORE PROTEINS ASSEMBLE ON THE HRE , FORMING THE TRANSCRIPTION COMPLEX = A TRANSIENT IV COMPLEX ESTRADIOL: ENHANCES SYN OF MANY PROTEINS; TIMESCALE HRS TO AFFECT PROTEIN CONC. BUT!! PROMOTING CELL GROWTH,
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 4
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 13

40 - LECTURE 40 THE VERY LAST ONE! ANNOUNCEMENTS 1. QUIZ 10...

This preview shows document pages 1 - 4. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online