APY248 Exam 1 Outline

APY248 Exam 1 Outline - Outline for APY 248 Exam 1...

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Unformatted text preview: Outline for APY 248 - Exam 1 ATTENTION: This outline is not, nor is it meant to be, all inclusive. Our interest is to merely provide a structure against which you can organize the material presented in class, i.e., an expanded syllabus. PLEASE NOTE: EXAM QUESTIONS WILL NOT BE LIMITED TO THE MATERIAL PRESENTED IN THIS OUTLINE. (See word list, your class notes, and textbook as well.) History of the development of human genetics Science and politics Lysenko - U.S.S.R. Biometricians (Galton and Pearson) Nature of the hereditary process Eugenics movement - England Eugenics movement - U. S. - tied to Mendelian inheritance Rassenhygiene - Germany Origin and maintenance of heritable variation Movie - DNA Chromosome behavior Mitosis - Where? When? Importance? Meiosis - Where? When? Importance? Sex determination Mendel’s laws of inheritance - behavior of genes in meiosis Law of Segregation - behavior of genes in meiosis Law of Independent assortment - behavior of a single pair of alleles Linkage and recombination Sex linkage - X inactivation Chromosomal abnormalities Polyploidy and aneuploidy Causes - meiotic and mitotic nondisjunction Sex chromosome aneuploidies - specific examples Pseudohermaphrodites - effect of genes and hormones on sex determination Autosomal aneuploidies Down syndrome - causes Nondisjunction, translocation, mosaics Relationship between genotype and phenotype DNA - mRNA - polypeptide chain - protein Concept of dominance Inheritance and Mendelian (phenotypic) ratios Effects of incomplete penetrance and variable expressivity Hemoglobin Genetic basis Causes of changes Malaria and natural selection Health effects of HbS Multiple hemoglobins during development Evolutionary origins Thalassemia Natural selection Genetic basis G-6-PD deficiency ...
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