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Unformatted text preview: Outline for APY 248 - Exam 1 ATTENTION: This outline is not, nor is it meant to be, all inclusive. Our interest is to merely provide a structure against which you can organize the material presented in class, i.e., an
expanded syllabus. PLEASE NOTE: EXAM QUESTIONS WILL NOT BE LIMITED TO THE MATERIAL
PRESENTED IN THIS OUTLINE. (See word list, your class notes, and textbook as well.) History of the development of human genetics Science and politics
Lysenko - U.S.S.R.
Biometricians (Galton and Pearson)
Nature of the hereditary process
Eugenics movement - England Eugenics movement - U. S. - tied to Mendelian inheritance
Rassenhygiene - Germany Origin and maintenance of heritable variation Movie - DNA
Mitosis - Where? When? Importance?
Meiosis - Where? When? Importance?
Mendel’s laws of inheritance - behavior of genes in meiosis
Law of Segregation - behavior of genes in meiosis
Law of Independent assortment - behavior of a single pair of alleles
Linkage and recombination
Sex linkage - X inactivation Chromosomal abnormalities Polyploidy and aneuploidy
Causes - meiotic and mitotic nondisjunction
Sex chromosome aneuploidies - speciﬁc examples Pseudohermaphrodites - effect of genes and hormones on sex determination
Autosomal aneuploidies Down syndrome - causes
Nondisjunction, translocation, mosaics Relationship between genotype and phenotype DNA - mRNA - polypeptide chain - protein
Concept of dominance
Inheritance and Mendelian (phenotypic) ratios
Effects of incomplete penetrance and variable expressivity Hemoglobin Genetic basis Causes of changes Malaria and natural selection Health effects of HbS Multiple hemoglobins during development
Evolutionary origins Thalassemia
Genetic basis G-6-PD deﬁciency ...
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- Spring '11
- Genetics, Eugenics Movement, genetic basis, thalassemia, sex chromosome aneuploidies