Unformatted text preview: Computation of F (inbreeding coefficient) Rules of Probability: l. The probability of the joint occurrence of independent events
is the product of the probabilities of each of the events. 2. The probability of the occurrence of one set of mutually
exclusive events is the sum of the probabilities of the individual events. Individual A is heterozygous
for alleles E and e. 1. The probability that A transmits E to
The probability that A transmits E to 1/2.
1/2. OUJ probability of both = 1/2 x 1/2 = 1/4. 2. The probability that B transmits E to I 1/2.
The probability that C transmits E to I 1/2. probability of both = 1/2 x 1/2 = 1/4 1/4 x 1/4 = 1/16. 3. The probability that both 1. and 2. occur This is the probability that I is EE, with both alleles derived from A.
Likewise, the probability that I is ee is 1/16. The probability that I is EE 9; ee is 1/16 + 1/16 = 1/8.
The inbreeding coefficient (F) of the offspring of halfsibs is 1/8. ...
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- Spring '11