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Essay 1 Donohue Syndrome

Essay 1 Donohue Syndrome - Name Kai Chen Course Name Issue...

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Name: Kai Chen Course Name: Issue in Biology Date: 02/12/10 Professor: Jay Wildt Assignment: Essay 1 Donohue Syndrome The Donohue syndrome is a very rare disease in the world, and it is a kind of hereditary disease. The pathogenesis of Donohue syndrome is cause to the disordered embryonic development. It is a kind of insulin receptor function deletion relative disease. This disease was first reported by Doctor. W’L Donohue in 1948, so it is also called Donohue Syndrome (Bruno and Bernard, 2006). Donohue Syndrome or leprechaunism includes delayed pre- and postnatal growth, decreased subcutaneous tissue, hirsutism, nail hypoplasia, and genital hypertrophy. It is caused by homozygous deletion of the insulin receptor gene, and certain symptoms resemble that of severe diabetes mellitus. (Wilson and Cooley, 2006) The main characteristics of Donohue Syndrome are obvious hyperinsulinemia, it has about 100 times insulin resistance than normal level. The other feature of Donohue Syndrome are Carbohydrate Tolerance are normal, but sometimes have fasting hypoglycemia, and most of patients are abnormalities, such as intrauterine growth stagnation, fetus stop growth after 7 th month, and died after 4 month from born, only extremely few patients can live for more than 10 years. The faces of Donohue Syndrome patients are usually smaller than normal, look like an elf in North Island Myth. That is why the Donohue Syndrome is also called Leprechaunism. The reason of give up
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