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Essay 1 Rewrite - Name Kai Chen Course Name Issue in...

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Name: Kai Chen Course Name: Issue in Biology Date: 04/11/11 Professor: Jay Wildt Assignment: Essay 1 Donohue Syndrome Donohue Syndrome was first reported by Doctor W. Donohue in 1948, and is therefore called Donohue Syndrome (Al-Tubaikh, 2009). Donohue Syndrome is a rare disease that occurs when a rare genetic mutation results in incomplete DNA, and cause delayed pre- and postnatal growth, decrease of fat below the skin, hair overgrowth, nail undergrowth, and oversized sex organs (Wilson and Cooley, 2006). Donohue Syndrome is a very rare disease in the world, and it is a kind of hereditary disease. The gene that controls blood sugar is not working properly. This affects the human’s response of the blood sugar content function. The main cause for Donohue Syndrome is gene mutations. One part of the human DNA is incomplete (Wilson and Cooley, 2006). Therefore, the incomplete DNA results in a defect of insulin resistance function for the human’s body. The heredity method of Donohue Syndrome is an autosomal recessive heredity. There are at almost 7,000,000 Donohue Syndrome gene carriers in total world population (Al-Tubaikh, 2009). With this small number, it can be seen that the special feature causing Donohue Syndrome is also rare. In practice, the gene mutations are very rare, and most show because of marrying with relatives. Because the mutated gene comes from parents, people who marry with relatives have a very high chance of carrying the Donohue Syndrome gene (Al-Tubaikh, 2009). Today medical technology is already able to detect whether or not the newborn is carrying the Donohue Syndrome gene. However, because of the chance of the Donohue Syndrome gene mutation is very low, the test does not need to become a regular program for newborn
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babies. Unless the parents have reason to believe that one of the relatives is a carrier, they should test whether their baby has this disease. As a kind of hereditary disease, the gene mutation of Donohue Syndrome has many possible causes and this is also not seen in a specific race. Today’s medical community has found this disease in many different races (Roderick, 2007). One of the main characteristics of Donohue Syndrome is an obvious low blood sugar content (Roderick, 2007). Because of the element controlling the blood sugar content is extremely lacking, this impacts pre-natal and post-natal growth. The other feature of Donohue Syndrome is patients sometimes may appear to have low blood sugar symptoms, even though the blood sugar tolerance level is normal (Roderick, 2007). Because of this feature, most Donohue Syndrome patients have abnormal growth problems. Some of the fetuses stop growing after the seventh month and die four months after birth. Only a few patients live for more than 10 years.
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