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By the 450s - Bythe450s,, , . circumstances:

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By the 450s, Rome-Constantinople conflicts had grown, as reflected in the doctrinal  controversies mentioned above, where something like a Alexandria-Rome axis opposed a  Constantinople-Antioch alliance. Part of the growing tension was related to objective  circumstances: Pope Leo I could not count on Eastern support when the Huns threatened to sack  Rome in 455, and in the absence of any real (Western or Eastern) imperial administration of  Rome, the Pope himself was forced to take on several temporal responsibilities, increasing his  own sense of esteem. That the senatorial aristocracy of Rome had been impoverished to the point  that the Church was much wealthier by comparison strengthened its status as popular patron, and  gave basis to the increasingly tenacious claims of Rome's bishops to preeminence. By this time  too, Germanic invaders were more prevalent in the West, and revered Rome, not Constantinople.  Furthermore, the proliferation of ecclesiastical positions in the West to which people were  elected, and about which disputes arose, required a third, impartial party to arbitrate. The Bishop 
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  • Fall '08
  • Murphy
  • Constantinople Patriarch, Chalcedon Council. Leo, so. Eastern clerics, royal power. Strife, increasingly tenacious claims

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