reg-notes - Regulation of gene expression I. General...

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Regulation of gene expression I. General information A. orderly and controlled expression growth phase, nutritional and stress conditions, environment vs. in host B. most regulation at initiation of transcription; however, some post-transcriptional - mRNA stability, translational regulation, post-translational C. operon - region of DNA (genes and required cis-active sites) expressed from same promoter therefore on same mRNA D. negative regulation - when active regulator turns off expression E. positive regulation - when active regulator turns on expression F. regulators - repressor - turn off binding to operators; activators - turn on binding to activator sites G. effector molecules - inducer - binds to repressor or activator to turn on expression corepressor - binds to repressor turning off expression H. location of operators and activators sites (Fig. 11.1) 1. operators near or downstream of promoter 2. activator sites - upstream of promoter I. constitutive mutant - always on - more difficult for positive regulation than
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reg-notes - Regulation of gene expression I. General...

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