Chapter 20 - Chapter 20 Microbial Diseases of the...

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Chapter 20 Microbial Diseases of the Cardiovascular and Lymphatic System Cardiovascular system Composed of three parts Heart Blood Blood vessels Heart pumps blood into arteries that are connected to veins via capillaries Arteries carry blood away from the heart Veins carry blood to the heart Lymphatic system Plasma can leave the blood vessels and circulate in the interstitial space (space between tissue cells). Plasma collects metabolic products and carries them to lymphatic system (it can also pick up the microbes and disseminate the infection). When inside the lymphatic system, plasma is called – lymph. Bacterial diseases Blood is normally sterile Bacteria can infect the blood, blood vessels, and heart Bacteremia – presence of bacteria in the blood Septicemia – microorgansims are actively multiplying in the blood Septic shock – condition in which Gr- bacteria release the endotoxin (can be caused by antibiotic treatment) Lymphangitis - Infection and inflammation of the lymphatic vessels Bacterial infection of the heart Endocarditis Involves inflammation of endocardium and heart valves Endocardium – the inner layer of heart muscle Two types of endocarditis Acute Subacute Subacute bacterial endocarditis The disease develops slowly Bacteria grow on preexisting lesions If not treated, the disease is fatal within a few months Caused by a-hemolytic streptococci. The microorganisms enter the blood during the tooth extraction or tonsillectomy. Prophylactic antibiotic treatment Acute bacterial endocarditis Staphylococcus aureus is transferred from original infection site to the heart (traumatic injury or surgical procedure) Colonize heart valves (vegetations) – cardiac malfunction It causes a rapid destruction of heart valves If untreated, can be fatal within a few days Plague (Black Death)
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Caused by Yersinia pestis – Gr- rod shaped bacteria Normally infects rats (other rodents) Transmitted by rat flea and airborne droplets Bacterium is injected by the bite of the flea Bacterium enters the blood and lymph where it proliferates. Symptoms: enlargement of lymph nodes in armpit and groins – buboes – bubonic
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Chapter 20 - Chapter 20 Microbial Diseases of the...

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