download+2 - AIDS FUNDAMENTALS Virology I Oct 6 2011 Althea...

Info icon This preview shows pages 1–9. Sign up to view the full content.

View Full Document Right Arrow Icon
AIDS FUNDAMENTALS Virology I: Oct. 6, 2011 Althea Capul, Ph.D. [email protected]
Image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Summary (from Oct. 4) Antibodies are generated against a multitude of antigens Clonal activation allows expansion and large release of antibody-producing B cells B cells that recognize normal (self) antigens are eliminated/suppressed
Image of page 2
Summary II (Oct. 4) Vaccines take advantage of antibody response by B cells and B cell activation Neutralize pathogens/toxins Minimize disease
Image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Summary III (Oct. 4) T cells Target infected cells for killing T killer cells (express CD8 on surface) Direct and activate the immune response for both B and T killer cells T helper cells (express CD4 on surface) Self vs. non-self (foreign) recognition is highly regulated
Image of page 4
Rabies vaccine FYI: www.cdc.gov/ncidod/dvrd/rabies Rabies vaccine is made from killed rabies virus. It cannot cause rabies. Pre-exposure 3 doses during a one-month span Post-exposure (unvaccinated) 4 doses during a two-week span One dose of Rabies Immune Globulin (Antibody)
Image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Virus All viruses are obligate intracellular parasites: viruses cannot replicate outside a host cell. Viruses contain nucleic acid (RNA or DNA) encased in a protein coat ( capsid ). Some viruses contain a second coating derived from a host cell membrane containing lipids and glycoprotein(s) called the envelope .
Image of page 6
Non-enveloped virus e.g. poliovirus Enveloped virus e.g. HIV FIGURE 01: Typical virus
Image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Virus-Host Cell Interaction I Virus supplies certain genes Structural proteins Enzymes for efficient replication Regulatory proteins Control viral gene expression Control host cell biology
Image of page 8
Image of page 9
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern