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AIDS FUNDAMENTALS Virology I: Oct. 6, 2011 Althea Capul, Ph.D. acapul@uci.edu
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Summary (from Oct. 4) Antibodies are generated against a multitude of antigens Clonal activation allows expansion and large release of antibody-producing B cells B cells that recognize normal (self) antigens are eliminated/suppressed
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Summary II (Oct. 4) Vaccines take advantage of antibody response by B cells and B cell activation Neutralize pathogens/toxins Minimize disease
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Summary III (Oct. 4) T cells Target infected cells for killing T killer cells (express CD8 on surface) Direct and activate the immune response for both B and T killer cells T helper cells (express CD4 on surface) Self vs. non-self (foreign) recognition is highly regulated
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Rabies vaccine FYI: www.cdc.gov/ncidod/dvrd/rabies Rabies vaccine is made from killed rabies virus. It cannot cause rabies. Pre-exposure 3 doses during a one-month span Post-exposure (unvaccinated) 4 doses during a two-week span One dose of Rabies Immune Globulin (Antibody)
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Virus All viruses are obligate intracellular parasites: viruses cannot replicate outside a host cell. Viruses contain nucleic acid (RNA or DNA) encased in a protein coat ( capsid ). Some viruses contain a second coating derived from a host cell membrane containing lipids and glycoprotein(s) called the envelope .
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Non-enveloped virus e.g. poliovirus Enveloped virus e.g. HIV FIGURE 01: Typical virus
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Virus-Host Cell Interaction I Virus supplies certain genes Structural proteins Enzymes for efficient replication Regulatory proteins Control viral gene expression Control host cell biology
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download+2 - AIDS FUNDAMENTALS Virology I: Oct. 6, 2011...

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