Lec18+2011 - Lecture 18: Human Genetics, Disease Wednesday...

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Lecture 18: Human Genetics, Disease Wednesday 11/02/11 18-1 Reading: Ch. 14, pp. 276-281 Supplements: Web Activity 15.2 Bio 93, O’Dowd and Warrior, UCI - Copyright: All rights reserved
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Variations from Classic Mendelian Genetics 5. Epistasis : a gene at one locus alters the phenotypic expression of a gene at a second locus. 4. Pleiotropy : one gene affects > one phenotypic character. 6. Polygenic inheritance : multiple genes are responsible for a phenotype. 7. Environmental impact : genetically identical individuals show different phenotypes as a result of environmental factors. 18-2 Bio 93, O’Dowd and Warrior, UCI - Copyright: All rights reserved 1. Incomplete dominance : heterozygotes have a phenotype intermediate to the two alleles. 2. Co-dominance : the phenotype of both alleles is fully expressed in heterozygotes. 3. Multiple alleles : more than two alleles affect a phenotype
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One gene affects > one phenotypic character. In sickle cell anemia mutation of one gene causes many symptoms. Fig. 14.15 18-3 Bio 93, O’Dowd and Warrior, UCI - Copyright: All rights reserved 4. Pleiotropy
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5. Epistasis 18-4 Bruce Willis has dominant alleles for the bald gene and the widow’s peak gene. The bald allele B is epistatic to widow’s peak W A gene at one locus alters the phenotypic expression of a gene at a second locus Bio 93, O’Dowd and Warrior, UCI - Copyright: All rights reserved
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Coat color in mice depends on two genes. Gene 1 determines whether the coat is black (
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This note was uploaded on 12/13/2011 for the course BIOSCI d103 taught by Professor Staff during the Fall '11 term at UC Irvine.

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Lec18+2011 - Lecture 18: Human Genetics, Disease Wednesday...

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