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Lec21+2011 - Lecture 21 From Genotype to Phenotype...

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Reading: Chapter 17, pages 325-348 Lecture 21: From Genotype to Phenotype Wednesday 11/09/11 Bio 93 Fall 2011 Reminder: In-class Quiz #2 on Monday11/14/11 Lectures 15-21 5 Questions; 2 points each NO make-up quizzes Friday 11/11 is Veteran’s Day – No Class Fall 2010, Bio 93, O Dowd and Warrior, UCI - Copyright: All rights reserved
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HOW DO YOU GO FROM GENOTYPE TO PHENOTYPE? An organism s genotype is carried in the sequence of bases The Central Dogma Bio 93, O Dowd and Warrior, UCI - Copyright: All rights reserved The phenotype is a consequence of the proteins that are expressed DNA RNA Protein Make sure to re-read Lecture 9
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Eukaryotes: Transcription occurs in the Nucleus Translation occurs mainly at ribosomes in the cytoplasm. The primary transcript is processed before export to the cytoplasm. Bacteria: Because bacteria lack nuclei , transcription and translation are coupled. Ribosomes attach to mRNAs while transcription is still in progress. Bacterial vs eukaryotic transcription and translation Bio 93, O Dowd and Warrior, UCI - Copyright: All rights reserved Fig. 17.3
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Bio 93, O Dowd and Warrior, UCI - Copyright: All rights reserved The Triplet Code Fig. 17.4 Study Hint: Pay close attention to the use of 3’ and 5’.
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