Lec1_Mitochondria_final

Lec1_Mitochondria_final - Change of Instructor Im Steve...

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1 D103 Cell Biology – SS1 2009 Lecture 9+10 © Grün - all rights reserved. Change of Instructor I’m Steve Gross you can call me either Steve or Dr. Gross, as you prefer My tentative office hours: Monday: 9-10 AM Wed: 10-11 AM If you have problems with both of these times (and care) email me; I’ll try to find an alternative time for one of them if enough people want me to. Questions are encouraged; if you are confused, others likely are too. 1 Cell Biology – lecture 1 © Gross - all rights reserved. D103 Cell Biology – SS1 2009 Lecture 9+10 © Grün - all rights reserved. Two alternatives for how I teach the class In the past, students have felt that I talk too fast. There is a lot of material to get through, some of it challenging. I know of only two ways to cover all the material: A) Talk more slowly, but assign more material as required reading, and not cover it in class, except if you ask questions about it B) Talk fast, and try to cover the majority of the material in class if at all possible. Note, you will still need to read some. You can vote, using your clickers for A) or B) 2 Cell Biology – lecture 1 © Gross - all rights reserved.
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2 D103 Cell Biology – SS1 2009 Lecture 9+10 © Grün - all rights reserved. 3 Cell Biology – lecture 1 © Gross - all rights reserved. (read p. 695-697, Alberts, 5 th ed) D103 Cell Biology – SS1 2009 Lecture 9+10 © Grün - all rights reserved. 4 Required Reading: MBOC, pages 813-827 , 855-866 2 main functions of mitochondria: ATP production Control of apoptosis Mitochondria biogenesis and inheritance mitochondrial genetic diseases Mitochondria Cell Biology – lecture 1 © Gross - all rights reserved.
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3 D103 Cell Biology – SS1 2009 Lecture 9+10 © Grün - all rights reserved. Actual Mitochondria and Lipid Droplets 5 Cell Biology – lecture 1 © Gross - all rights reserved. Mitochondria: 22% of cell volume, can be 1700/cell ! D103 Cell Biology – SS1 2009 Lecture 9+10 © Grün - all rights reserved. Mitochondria: overview I. What do mitochondria do for the cell? Convert food molecules into energy for the cell through oxidative phosphorylation (ATP production) Crucial players in Apoptosis (Programmed cell death) II. Mitochondrial structure and organization Double-membraned organelle Abundant Distributed throughout the cell Dynamic! III. Mitochondria contain DNA ! 6 Cell Biology – lecture 1 © Gross - all rights reserved.
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4 D103 Cell Biology – SS1 2009 Lecture 9+10 © Grün - all rights reserved. ATP (the key energy source of a cell) is generated in the mitochondria pyruvate (3C), acetyl-CoA (2C) intermediates ATP amino acids, simple sugars (6C), fatty acids 7 Cell Biology – lecture 1 © Gross - all rights reserved. ATP Production: overview Cartoon of Mitochondria Outer membrane: Permeable to small molecules due to presence porin protein (form aqueous pores that allow for movement of small molecules <5 kD) Impermeable to proteins (e.g. cytochrome c) unless they are specifically transported across
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This note was uploaded on 12/13/2011 for the course BIOSCI d103 taught by Professor Staff during the Fall '11 term at UC Irvine.

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Lec1_Mitochondria_final - Change of Instructor Im Steve...

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